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Description
TCI D3912 2,4-Dichloro-4'-nitrobiphenyl Ether (CAS 1836-75-5) is a substituted diphenyl ether compound classified among non-heterocyclic building blocks. Its molecular structure joins two aromatic rings through an oxygen bridge, carrying two chlorine atoms on one ring and a nitro group on the other. In the laboratory, this compound serves both as a synthetic starting material and as a comparison substance in environmental chemistry research and in the analysis of halogenated aromatic compounds, where a clearly defined reference structure is required for reliable interpretation of results.
The principal characteristic that makes this compound a preferred choice is its substitution pattern, which activates the aromatic ring toward nucleophilic substitution reactions. The nitro group acts as a strong electron-withdrawing substituent while also remaining available for reduction to an amino group at a later synthetic stage, giving chemists two distinct routes from a single starting material. The diphenyl ether bridge provides a framework that is reasonably stable under many reaction conditions, so modification work can be concentrated on the functional groups of interest. The consistent reagent quality associated with TCI helps researchers compare results across experiments without having to account for variation in starting materials.
In Indonesian laboratories, this compound is widely used in synthetic organic chemistry research and in environmental chemistry studies. It supports work in university research groups and institutional laboratories where halogenated aromatic compounds are investigated, whether as intermediates in a preparative sequence or as defined reference structures during method development and analytical comparison. Its role is typically that of a dependable, well-characterised building block within a broader research programme rather than a stand-alone endpoint.
Laboratory Applications
Synthetic starting material — the activated aromatic ring and reducible nitro group allow this compound to be carried forward through multi-step preparative sequences with predictable reactivity.
Nucleophilic aromatic substitution studies — the strong electron-withdrawing nitro group and adjacent halogen substituents make it a suitable substrate for investigating substitution mechanisms and reaction conditions.
Environmental chemistry research — as a defined halogenated aromatic structure, it serves as a comparison substance in studies concerned with the behaviour of such compounds.
Analysis of halogenated aromatic compounds — its clearly defined structure allows it to function as a reference material when analytical methods for this compound class are being developed or verified.
Nitro-to-amino conversion work — the nitro group can be reduced to an amino group in a later stage, making this compound useful for preparing aminated diphenyl ether derivatives.
Specifications
Brand: TCI (Tokyo Chemical Industry)
CAS number: 1836-75-5
Chemical name: 2,4-Dichloro-4'-nitrobiphenyl Ether
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes: available in standard research-scale laboratory pack sizes; please confirm the currently available packaging when ordering
Storage: keep in the original tightly closed container, protected from light and moisture, in accordance with the manufacturer's stated conditions
Handling and Storage
Store this reagent in its original tightly closed container in a cool, dry, well-ventilated area, protected from direct sunlight and moisture, and follow the specific storage conditions stated on the manufacturer's label and safety data sheet. Amber glass or the supplied original packaging is appropriate for maintaining sample integrity. Handle in a fume hood using nitrile gloves, safety glasses, and a laboratory coat, and avoid inhalation of dust and contact with skin or eyes. Keep the container away from strong reducing agents and sources of ignition, weigh out only the required quantity to limit exposure of the bulk material, and collect halogenated organic waste separately according to institutional disposal procedures.
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