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Description
TCI D4302 is Doxofylline, a xanthine derivative that is structurally related to theophylline but carries a dioxolane group at a ring nitrogen position. The compound is classified as an alkaloid within the biochemicals and reagents category, and it is known in pharmacology as a bronchodilator of the methylxanthine class. In the laboratory, reagent-grade material of this kind is used as a reference substance for analytical method development, formulation research, and basic pharmacological studies, rather than for use in humans or animals without appropriate ethical approval.
The property that makes this compound important to laboratories is its clearly defined xanthine skeleton together with the dioxolane group that distinguishes it from theophylline, allowing the substance to serve as a structural comparator in structure-activity relationship studies. As a xanthine derivative, it possesses carbonyl groups and ring nitrogens that give characteristic ultraviolet absorption, which is highly useful for detection in high performance liquid chromatography as well as in spectrophotometry. Its moderate solubility in aqueous media and polar organic solvents simplifies the preparation of standard solutions for calibration curves, and reagent-grade purity supports consistent, reproducible measurements.
In Indonesian laboratories, material of this grade is typically found in pharmaceutical quality control units, analytical chemistry laboratories, university research groups, and formulation development facilities. It is generally handled as a reference material for method validation and comparative work, prepared in small quantities as stock and working standards. Use is confined to research and analytical settings, and any biological or pharmacological investigation is expected to follow the relevant ethical and institutional approvals that apply to the work being carried out.
Laboratory Applications
- Analytical method development, where the defined xanthine skeleton and characteristic ultraviolet absorption allow reliable peak identification and detector response during HPLC method setup.
- Reference standard preparation for calibration curves, since moderate solubility in aqueous media and polar organic solvents makes accurate stock and working solutions straightforward to prepare.
- Structure-activity relationship studies, because the dioxolane group distinguishes this compound from theophylline and provides a useful structural comparator within the methylxanthine series.
- Formulation research, where reagent-grade material of consistent quality supports comparative experiments on solubility behaviour and compatibility during early development work in the laboratory.
- Basic pharmacological research on methylxanthine bronchodilators, conducted strictly within research settings and subject to the ethical approvals required for any biological or animal work.
Specifications
- Brand: TCI
- CAS Number: 69975-86-6
- Category: Life Science > Biochemicals and Reagents > Alkaloids
- Compound class: xanthine derivative, classified as an alkaloid
- Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required quantity when ordering
- Storage: keep in the closed original container under the conditions stated on the manufacturer's label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated area, protected from direct sunlight, moisture, and sources of heat or ignition, and follow the storage conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original container or in a chemically compatible, clearly labelled glass or high-density polyethylene vessel. Handle the solid in a fume hood or well-ventilated area to avoid generating dust, and wear a laboratory coat, safety glasses, and suitable chemical-resistant gloves. Weigh out only the amount required, close the container promptly to limit moisture uptake, and consult the safety data sheet before use. Dispose of residues and contaminated materials as chemical waste in accordance with institutional and local regulations.
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