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Description
7-(2,3-Dihydroxypropyl)theophylline is a xanthine derivative formed by attaching a dihydroxypropyl chain to the nitrogen at position seven of the theophylline skeleton. The compound belongs to the purine alkaloid group and is catalogued under biochemicals and life science reagents. In the laboratory it is used as a reference material, as a test substance for pharmacological work, and as a study material in formulation research, because the xanthine skeleton has long been associated with airway smooth muscle relaxation activity and phosphodiesterase inhibition in basic research.
The characteristic that makes this compound a frequent choice is the diol group on its side chain. The two hydroxyl groups increase the hydrophilic character of the molecule compared with theophylline itself, so its solubility in aqueous media is considerably better. This property is a real advantage when researchers need to prepare stock solutions for biological assays, dissolution testing, or chromatographic analysis without depending on large volumes of organic solvent. The conjugated xanthine skeleton also gives a distinctive ultraviolet absorbance, so the compound is easy to monitor with a UV detector on an HPLC system or with a spectrophotometer.
In Indonesian laboratories, this material fits the routine work of university research groups, pharmaceutical quality control units, and analytical service laboratories that handle xanthine derivatives. Its good aqueous solubility simplifies sample preparation in settings where organic solvent handling is kept to a minimum, and its clear UV absorbance suits the HPLC and spectrophotometer instrumentation that is already standard equipment in most local analytical and formulation laboratories.
Laboratory Applications
Analytical reference standard — the distinctive ultraviolet absorbance of the xanthine skeleton allows straightforward identification and quantification using UV detection on HPLC systems or a spectrophotometer.
Pharmacological screening — the compound serves as a test substance in basic research on phosphodiesterase inhibition and airway smooth muscle relaxation associated with the xanthine framework.
Formulation development studies — the diol side chain improves hydrophilic character, making the material suitable for formulation research where aqueous behaviour of a xanthine derivative is being examined.
Dissolution testing — much better solubility in aqueous media than theophylline itself lets researchers prepare and study dissolution samples without relying on large volumes of organic solvent.
Stock solution preparation for biological assays — the two hydroxyl groups support dissolution in aqueous buffer systems, simplifying preparation of working solutions for cell-based and enzymatic experiments.
Specifications
Brand: TCI
Catalogue code: D3600
CAS number: 479-18-5
Category: Life Science > Biochemicals and Reagents > Alkaloids
Pack sizes: available in the standard catalogue pack sizes offered by TCI for this product
Storage: store according to the conditions stated on the manufacturer's label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry place, away from direct sunlight, moisture, and incompatible chemicals, following the storage conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original container or in a clean, well-sealed glass or chemically compatible plastic vessel that is clearly labelled with the substance name and CAS number. Handle the compound in a well-ventilated area or a fume hood, and wear standard personal protective equipment including a laboratory coat, safety glasses, and suitable gloves. Avoid generating dust, avoid contact with skin and eyes, and use clean, dry spatulas when weighing to prevent contamination of the stock. Consult the safety data sheet before use and dispose of residues in accordance with local laboratory waste regulations.
