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Description
TCI D4630 is 1,5-Dimethylpyrazole, a five-membered heterocyclic compound containing two adjacent nitrogen atoms and carrying methyl groups at the nitrogen in position 1 and at the carbon in position 5. As a heterocyclic building block, this compound serves as a useful starting material for constructing more elaborate pyrazole derivatives, a class of compounds very commonly encountered in both pharmaceutical active ingredients and agrochemicals. In the laboratory, the material is used for ring functionalisation reactions, ligand synthesis, and the assembly of test compound libraries built around the pyrazole core, which is widely recognised for its versatility.
The properties that make this compound attractive are the combination of the aromaticity of the pyrazole ring and the influence of its methyl substitution. Because the nitrogen at position 1 is already methylated, the ring no longer carries an exchangeable N–H proton, so the tautomerism problems that normally complicate work with unsubstituted pyrazoles disappear and reaction outcomes become more predictable. The second nitrogen remains weakly basic and is able to coordinate to metal centres, which makes this compound a practical ligand precursor. In addition, the electron-rich pyrazole ring readily undergoes directed electrophilic substitution on the ring.
In Indonesian laboratories, this building block is typically drawn on in synthetic organic chemistry work at universities and research institutes, as well as in the development laboratories of pharmaceutical and agrochemical producers. It is used at the exploratory and small-scale synthesis stage, where a well-defined, predictable pyrazole starting material shortens route development and makes results easier to reproduce between analysts. The same material also supports coordination chemistry and catalysis studies where a methylated pyrazole is required as a ligand precursor.
Laboratory Applications
- Pyrazole derivative synthesis — the defined 1,5-dimethyl substitution pattern gives a fixed, unambiguous starting point for building more elaborate pyrazole scaffolds step by step.
- Ring functionalisation chemistry — the electron-rich aromatic ring undergoes directed electrophilic substitution, allowing new substituents to be introduced onto the pyrazole core in a controlled manner.
- Ligand synthesis for coordination chemistry — the remaining weakly basic nitrogen can coordinate to metal centres, making this compound a practical precursor for methylated pyrazole-type ligands.
- Compound library assembly — the pyrazole core is a versatile and frequently used motif, so this material suits the preparation of test compound sets for screening programmes.
- Pharmaceutical and agrochemical discovery support — pyrazole derivatives are very common in active ingredients, so this building block is well matched to early-stage route exploration in both fields.
Specifications
- Brand: TCI
- CAS number: 694-31-5
- Chemical name: 1,5-Dimethylpyrazole
- Catalogue reference: D4630
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Pack sizes: available in the standard laboratory pack sizes offered for this catalogue item; please confirm the size required when ordering
- Storage: keep in the closed original container under the storage conditions stated on the product label and safety data sheet
Handling and Storage
Store the container tightly closed in a cool, dry, well-ventilated place, away from heat, direct sunlight, ignition sources, and incompatible chemicals, and follow the storage conditions given on the product label and safety data sheet. Keep the material in its original supplier container wherever possible; if transfer is necessary, use a clean, chemically compatible and clearly labelled container. Handle in a fume hood using safety glasses, gloves, and a laboratory coat, avoid inhalation and skin or eye contact, and close the container immediately after use. Read the safety data sheet before first use and dispose of residues and contaminated materials as chemical waste according to applicable institutional and local regulations.
