1-Ethylpyrrolidine TCI E0510

Chemical Identity

CAS No.: 7335-06-0
PubChem: CID 81782·SID 87569759
Formula: C6H13N
Molecular weight: 99.18 g/mol
Purity: >98.0%(GC)
Reference databases: ChEBI

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 1-ethylpyrrolidine
SMILES: CCN1CCCC1
InChIKey: ONQBOTKLCMXPOF-UHFFFAOYSA-N
MDL: MDL01632186

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TCI E0510 1-Ethylpyrrolidine is a simple cyclic tertiary amine built from a saturated five-membered pyrrolidine ring carrying an ethyl group on the nitrogen atom. In the laboratory it serves principally as an organic base and as a small building block in organic synthesis. Because it is a tertiary amine with no hydrogen remaining on nitrogen, it can capture the protons generated during acylation, alkylation, or sulfonylation reactions without itself reacting to form amide by-products, which makes it a frequent choice whenever a chemist needs a clean acid scavenger rather than a reagent that competes with the substrate.

The properties that make this compound attractive include adequate basicity, a small molecular size, and the ease with which it can be separated from a reaction mixture once its work is done. Because the compound is volatile and dissolves readily in common organic solvents, residual base can usually be removed by evaporation or by a dilute acid wash without any elaborate purification procedure. The pyrrolidine ring also gives a steric profile that differs from triethylamine, so it sometimes delivers better results in reactions that are sensitive to steric hindrance around the reactive centre. As a consequence of that same volatility, the material is flammable and carries a strong amine odour.

In Indonesian laboratories the compound is typically ordered by synthetic chemistry groups in university research laboratories, by pharmaceutical and fine-chemical research and development units, and by analytical method development teams who need a reliable tertiary amine base on hand. It is generally used in small to moderate quantities on the bench rather than at process scale, and it is normally handled inside a working fume hood as part of ordinary multi-step synthesis and derivatisation work.

Related TCI products

Acid scavenging in acylation reactions, where the tertiary nitrogen neutralises the acid generated without forming amide by-products that would complicate the product isolation.
Base for alkylation chemistry, since it accepts the proton released during substitution while its lack of an N–H bond prevents it from competing as a nucleophile.
Proton capture in sulfonylation reactions, where a clean, non-reactive organic base is required to drive sulfonyl transfer to the intended substrate.
Heterocyclic building block in organic synthesis, contributing a compact saturated pyrrolidine ring that can be incorporated into larger target molecules by research chemists.
Alternative base screening against triethylamine, because the pyrrolidine ring offers a different steric profile that can improve yields in sterically sensitive transformations.

Brand	TCI
CAS number	7335-06-0
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes	supplied in the standard TCI catalogue pack sizes for this product code
Physical form	volatile liquid with a strong characteristic amine odour
Storage	keep tightly closed in a cool, well-ventilated place away from ignition sources

Product code: E0510

Store the container tightly closed in a cool, dry, well-ventilated area, away from open flames, hot surfaces, sparks, and other ignition sources, and separated from strong acids and strong oxidising agents. Keep the material in its original tightly sealed supplier bottle or in an equivalent chemically compatible container with a secure closure, since the compound is volatile and will escape and produce a strong amine odour from a loosely capped vessel. All transfers, weighing, and reaction set-up should be carried out inside a functioning fume hood, with safety glasses, a laboratory coat, and chemically resistant gloves worn throughout. Use non-sparking tools and ground containers where larger volumes are transferred, keep working quantities on the bench to a minimum, and clean up any spill promptly with an inert absorbent before disposing of it through the laboratory's normal chemical waste route.

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