Etodolac TCI E0858

Name: TCI E0858 41340-25-4 Etodolac
Brand: TCI
SKU: TCI2510E085828658
Price: 1741950.0 IDR
Availability: InStock

Rp 1.741.950,00

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Berat 5g 25g

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Description

Etodolac is a non-steroidal anti-inflammatory compound built on a pyrano-indole acetic acid framework, and it is widely stocked as a research material in pharmaceutical and biomedical laboratories. In a research setting, this compound serves as a comparison substance for studies of cyclooxygenase enzyme inhibition, as a test material in the development of dosage form formulations, and as a subject of pharmaceutical analysis work. Because its mechanism of action has already been studied in depth, etodolac is frequently adopted as a reference compound whenever researchers evaluate new candidates directed at the prostaglandin biosynthesis pathway.

The characteristic that makes this compound scientifically interesting is its tendency toward selectivity for the cyclooxygenase-2 isoform over cyclooxygenase-1, a property that has made it an important point of reference in discussions of the structure–activity relationships of COX inhibitors. The molecule is chiral and carries a carboxylic acid group, so it is also used extensively as a model substance in the development of enantiomer separation methods using chiral column chromatography. Its weakly acidic nature and pH-dependent solubility make it an informative substrate in dissolution and permeability studies.

In Indonesian laboratories, etodolac supplied under the TCI brand is typically used within pharmacy faculty research groups, pharmaceutical analysis teaching laboratories, and formulation development units. It supports coursework and thesis projects that examine anti-inflammatory activity, as well as method validation work in quality control laboratories. Research groups working on prostaglandin pathway inhibitors commonly keep the material on hand as a known comparator against which newly synthesised candidates can be assessed.

Laboratory Applications

Cyclooxygenase inhibition assays — the compound acts as a well-characterised comparison substance, so researchers can benchmark the inhibitory response of new candidates against a reference whose behaviour toward COX enzymes is already documented.
Structure–activity relationship studies of COX inhibitors — its tendency toward COX-2 over COX-1 selectivity makes it a standard talking point and reference structure when correlating molecular features with inhibitory selectivity.
Chiral separation method development — because the molecule is chiral and bears a carboxylic acid group, it works as a practical model analyte for building and optimising enantiomer resolution on chiral column chromatography systems.
Dosage form formulation development — the material serves as a test substance for formulation trials, allowing formulators to work through excipient compatibility and preparation design using a compound with established research literature.
Dissolution and permeability studies — its weakly acidic character and pH-dependent solubility yield informative release and transport profiles across different media, making it a useful probe substrate for biopharmaceutical characterisation work.

Specifications

Brand: TCI (Tokyo Chemical Industry)
CAS number: 41340-25-4
Product code: E0858
Category: Life Science > Biochemicals and Reagents > Enzymes, Enzyme Inhibitors, Enzyme Substrates
Pack sizes: available in standard research-scale packaging; please confirm the size options when ordering
Storage: store according to the conditions stated on the manufacturer's label and safety data sheet

Handling and Storage

Store the container in a cool, dry place that is well ventilated and shielded from direct sunlight, following the conditions printed on the manufacturer's label and safety data sheet. Keep the material in its original tightly closed container, or transfer it to a clean, chemically compatible vessel that is clearly labelled and protected from moisture. Handle the compound in a fume hood or a well-ventilated area while wearing a laboratory coat, gloves, and safety glasses, and avoid generating dust during weighing and transfer. As with any research chemical intended for laboratory use only, review the safety data sheet before first use, keep the container closed when not in use, and dispose of residues and contaminated materials through the laboratory's established chemical waste procedures.