TCI
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Description
TCI E1541 Sennoside A is a dianthrone glycoside that occurs naturally in the leaves and pods of senna plants (Cassia angustifolia and Cassia acutifolia) as well as in rhubarb rhizome. The molecule is built from two anthrone units bound to each other, each carrying a glucose sugar group on either side. In the laboratory, Sennoside A serves as an important reference material for studies in glycoscience, phytochemistry, and quality control of traditional medicinal materials. It functions as a primary chemical marker used to confirm the authenticity and consistency of senna crude drug material circulating as raw material for jamu and standardised herbal medicines.
The property that makes this compound a preferred choice is the distinctiveness of its structure as a marker that is not easily confused with others. The glycosidic bonds at both ends of the molecule give rise to a characteristic ultraviolet absorption pattern and a characteristic chromatographic retention time, making it readily recognisable in high performance liquid chromatography as well as in thin layer chromatography. Sennoside A is also the stereoisomeric partner of Sennoside B, so the two are frequently analysed together to assess the content ratio in a raw material. As a glycoside, the compound is relatively polar and dissolves better in mixed solvent systems than in purely non-polar media.
In Indonesian laboratories, Sennoside A is typically used where senna-derived raw materials must be verified before they enter a formulation or a finished product. Quality control laboratories serving the herbal medicine and standardised phytopharmaceutical sector rely on it to anchor identification and content determination methods, while university and research laboratories use it in phytochemistry teaching and in glycoscience investigations of naturally occurring glycosidic compounds.
Laboratory Applications
- Chemical marker identification of senna simplicia, where the distinctive structure of Sennoside A allows analysts to confirm that incoming raw material is genuinely derived from senna rather than a substituted plant material.
- High performance liquid chromatography reference standard work, since the characteristic retention time and ultraviolet absorption pattern of the compound give a reliable reference peak against which sample chromatograms are compared.
- Thin layer chromatography screening of herbal raw materials, because the compound produces a recognisable spot position that supports rapid preliminary identification before more elaborate instrumental confirmation is undertaken.
- Paired analysis with Sennoside B for stereoisomer ratio assessment, allowing laboratories to evaluate the relative content of the two isomers in a given batch of raw material.
- Glycoscience and phytochemistry research on dianthrone glycosides, where the defined glycosidic linkages at both molecular ends make the compound a useful model for studying sugar-bearing natural products.
Specifications
- Brand: TCI
- CAS Number: 81-27-6
- Category: Chemistry > Chemical Biology > Glycoscience
- Compound class: dianthrone glycoside bearing glucose groups on both anthrone units
- Pack sizes: available in standard TCI catalogue pack sizes; please confirm the required size when ordering
- Storage: store under the conditions stated on the product label and in the accompanying documentation
Handling and Storage
Store Sennoside A in a cool, dry place away from direct sunlight, following the storage conditions stated on the product label and supplier documentation. Keep the material in its original tightly closed container, preferably amber glass or another light-protecting container, to limit exposure to light and moisture that may affect a glycosidic compound. Handle the substance in a well-ventilated area or fume hood using standard laboratory personal protective equipment, including gloves, a laboratory coat, and eye protection. Avoid generating dust during weighing, close the container promptly after use, and label any prepared solutions clearly with contents and preparation date. Dispose of residues and contaminated materials in accordance with the applicable laboratory chemical waste procedures.
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