Histamine Dihydrochloride TCI H0146

Chemical Identity

CAS No.: 56-92-8
PubChem: CID 5818·SID 87570589
Formula: C5H9N3.2HCl
Molecular weight: 184.06 g/mol
Purity: >98.0%(HPLC)(T)
Reference databases: ChemSpider·ECHA·Wikipedia

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2-(1H-imidazol-5-yl)ethanamine;dihydrochloride
SMILES: C1=C(NC=N1)CCN.Cl.Cl
InChIKey: PPZMYIBUHIPZOS-UHFFFAOYSA-N
MDL: MDL00012703

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Histamine Dihydrochloride is the dihydrochloride salt form of histamine, a biogenic amine built around an imidazole ring that plays an important role in the immune system, allergic responses, and the regulation of gastric acid secretion. This product is supplied by TCI under catalogue code H0146 and carries CAS number 56-92-8. Converting the free base into its salt form yields a stable solid that is straightforward to weigh out and dissolves readily in water, making it considerably more practical to handle in routine laboratory work than the free base itself.

The properties that make this material a preferred choice begin with the stability of the salt form, which allows it to be stored and handled as a conventional solid reagent. Its high water solubility means stock solutions can be prepared quickly and reproducibly without recourse to organic co-solvents. Beyond its physical handling characteristics, the compound offers biological activity that has been very thoroughly characterised across the various histamine receptor subtypes, giving researchers a well-understood reference point. The imidazole ring within its structure also makes this compound an important representative of the nitrogen-containing heterocyclic building block class.

In Indonesian laboratories, this material is typically used as an analytical reference compound, as an agonist in pharmacological receptor research, and as a positive control in testing related to allergic reactions. The availability of 1 g, 5 g, and 25 g pack sizes gives flexibility both to laboratories that need only small quantities of reference material and to those running repeated, routine testing programmes, so the pack can be matched to the actual consumption rate of the facility.

TCI brochures (PDF)

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Related TCI products

Analytical reference standard preparation, where the stable, easily weighed salt form allows accurate reference solutions to be made up for comparison against sample results.
Pharmacological receptor research as an agonist, drawing on biological activity that is already very well characterised across the different histamine receptor subtypes studied.
Positive control material in allergy-related testing, providing a known-active reference against which assay responses and method performance can be verified.
Heterocyclic building block work in synthetic chemistry, since the imidazole ring makes it a representative example of nitrogen-containing heterocyclic structures.
Routine stock solution preparation for repeated assays, as the high water solubility lets laboratories prepare aqueous solutions quickly without additional solubilising agents.

Brand	TCI, catalogue code H0146
CAS number	56-92-8
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Heterocyclic Building Blocks
Pack sizes	1 g, 5 g, and 25 g
Physical form	solid (salt form of histamine), readily soluble in water
Storage	keep in the tightly closed original container, protected from moisture

Store the material in its original, tightly closed container in a cool, dry place away from moisture and direct sunlight, since the salt should be kept free-flowing and easy to weigh. Amber glass or the supplier's original packaging is suitable for storage, and prepared aqueous stock solutions should be kept in clearly labelled, sealed containers. Handle the powder in a well-ventilated area or fume hood to avoid inhaling dust, and wear gloves, safety glasses, and a laboratory coat when weighing or transferring. Because this compound is biologically active, avoid skin contact and ingestion, close the container promptly after use, and consult the supplier's safety data sheet before first use and for disposal guidance.

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