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CAS 2650-53-5

Hexyltrimethylammonium Bromide TCI H0534

Hexyltrimethylammonium Bromide TCI H0534
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TCI H0534 Hexyltrimethylammonium Bromide is a short-to-medium chain quaternary ammonium salt that functions both as a phase transfer catalyst and as a cationic surfactant in organic synthesis work. Its molecule consists of a positively charged trimethylammonium group bonded to a hexyl chain, with a bromide ion serving as the counter ion. This amphiphilic structure is precisely what allows the compound to carry reactive anions from the aqueous phase into the organic phase, so that reactions which would otherwise proceed slowly because the two reagents sit in different phases can run far more efficiently under milder laboratory conditions.

The properties that make this reagent a preferred choice are its good solubility in both water and polar organic solvents, its stability toward strong bases, and the ease with which it is handled as a solid that can be weighed directly without special equipment. The length of the hexyl chain provides a balance between hydrophilic and lipophilic character, which makes it suitable for liquid-liquid as well as solid-liquid two-phase systems. As a cationic surfactant, the compound also forms micelles above a certain concentration and can modify the surface charge of particles, a property that is exploited in synthesis work.

In Indonesian laboratories, this reagent is typically used in organic synthesis research at universities and in industrial research and development units, where two-phase reaction systems are routine. It is chosen where a reaction needs to be driven under milder conditions rather than through elevated temperature or aggressive solvents, and its handling as a weighable solid suits teaching and research laboratories that do not have specialised dispensing equipment on hand.

  • Phase transfer catalysis in liquid-liquid systems, where the amphiphilic structure ferries reactive anions from the aqueous phase into the organic phase so the reaction proceeds efficiently under milder conditions.
  • Phase transfer catalysis in solid-liquid systems, since the balanced hydrophilic and lipophilic character of the hexyl chain suits reactions in which one reagent remains an undissolved solid.
  • Base-mediated organic synthesis under two-phase conditions, where the stability of this quaternary ammonium salt toward strong bases allows it to survive the reaction environment intact.
  • Micelle-based reaction work, because the compound assembles into micelles above a certain concentration and thereby creates an organised medium for reagents in aqueous systems.
  • Surface charge modification of particles in synthesis, exploiting the cationic character of the trimethylammonium head group to alter how particles behave in the reaction mixture.

Brand TCI
CAS number 2650-53-5
Molecular formula —
Purity —
Category Chemistry > Synthetic Reagents > Phase Transfer Catalysts
Pack sizes available in the standard TCI catalogue pack sizes; please confirm the size required when ordering.
Physical form solid, able to be weighed directly without special equipment
Storage keep in a tightly closed container in a cool, dry place

Store the container tightly closed in a cool, dry place away from moisture, since quaternary ammonium bromide salts are prone to picking up water from humid air, which is a practical concern in the Indonesian climate. Original supplier containers or tightly sealing glass or plastic bottles are appropriate, and the cap should be replaced immediately after weighing. Handle the solid in a well-ventilated area or a fume hood to avoid raising dust, and wear standard laboratory personal protective equipment including a lab coat, safety glasses, and chemical-resistant gloves. Use a clean, dry spatula for each withdrawal to avoid contaminating the bulk material, and keep the compound away from strong oxidising agents. Wash hands thoroughly after handling.

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