Linolenic Acid TCI L0050

Chemical Identity

CAS No.: 463-40-1
PubChem: CID 5280934·SID 87572018
Formula: C18H30O2
Molecular weight: 278.4 g/mol
Purity: >70.0%(GC)
Reference databases: ChEBI·ChemSpider·ECHA·Wikipedia

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid
SMILES: CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)O
InChIKey: DTOSIQBPPRVQHS-PDBXOOCHSA-N

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TCI L0050 Linolenic Acid (CAS 463-40-1) is a polyunsaturated fatty acid with an eighteen-carbon chain and three double bonds. It belongs to the omega-3 fatty acid family and occurs naturally in many vegetable oils, such as flaxseed oil. In the laboratory, linolenic acid is used in two quite different fields. The first is biochemistry and nutrition, where researchers study lipid metabolism. The second is materials science, where it serves as a ligand or surfactant in the synthesis of colloidal nanocrystals and quantum dots.

Researchers choose linolenic acid because its carboxylate group can bind to the surface of metal or semiconductor nanocrystals. Its long hydrocarbon chain keeps the particles dispersed in nonpolar organic solvents. The three double bonds give the chain a more bent shape than a saturated fatty acid has. This bent shape affects how densely the ligand layer packs and how soluble the particles are, which makes linolenic acid a useful point of comparison with oleic acid. Its high degree of unsaturation also makes it more prone to oxidation, so it needs careful handling.

In Indonesia, university and research laboratories are working on nanomaterials and quantum dots for sensors, imaging, and optoelectronic devices. In these groups, linolenic acid is a practical reagent for studying how ligand structure affects nanocrystal growth, colloidal stability, and surface chemistry. Biochemistry and food science laboratories also use it as a reference compound when they study lipid metabolism and omega-3 fatty acids. TCI is a recognized brand, so it is easier to keep results consistent across repeated experiments.

TCI brochures (PDF)

Regenerative Medicine Research Reagents 2016-03-18 · p. 2
Colloidal Quantum Dot (QD) Research Reagents 2026-05-21 · p. 4
Lipids 2025-12-17 · p. 5
Reagents for Biological Research 2025-03-11 · p. 38

Related TCI products

Colloidal quantum dot synthesis: the carboxylate group binds to semiconductor nanocrystal surfaces, so linolenic acid can act as a capping ligand that controls growth and stabilizes the particles.
Metal nanocrystal preparation: as a surfactant, its long hydrocarbon chain keeps metal nanoparticles dispersed in nonpolar organic solvents and helps prevent unwanted aggregation during and after synthesis.
Ligand structure comparison studies: its three double bonds give it a more bent chain than oleic acid, which lets researchers test how ligand shape affects packing density and solubility.
Lipid metabolism research: as a naturally occurring omega-3 fatty acid, it suits biochemistry and nutrition studies that look at how polyunsaturated fatty acids are processed and transformed.
Oxidation and stability studies: its high unsaturation makes it sensitive to oxidation, so it is a relevant model compound for studying the oxidative degradation of polyunsaturated lipids and ligand shells.

Brand	TCI (product code L0050)
CAS number	463-40-1
Molecular formula	—
Purity	—
Category	Materials Science > Electronic Materials > Colloidal Quantum Dot (QD) Research Reagents
Pack sizes	Please contact AMI Scientific to confirm the pack sizes currently available
Physical form	—
Storage	Sensitive to oxidation; store tightly sealed, protected from air, light, and heat

Chemical class: Polyunsaturated omega-3 fatty acid, C18 chain with three double bonds

Linolenic acid is highly unsaturated and oxidizes easily, so store it in its original tightly closed container in a cool, dark place away from heat and direct light. Where possible, flush the container headspace with an inert gas such as nitrogen or argon after each use. Use glass or other chemically compatible containers, and keep exposure to air short when you dispense it. Wear standard laboratory protective equipment, including gloves, safety glasses, and a lab coat. Work in a well-ventilated area. Always read the supplier's Safety Data Sheet for specific hazard and storage instructions before use.

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