Tetraethylene Glycol TCI T0099

Chemical Identity

CAS No.: 112-60-7
PubChem: CID 8200·SID 87576111
Formula: C8H18O5
Molecular weight: 194.23 g/mol
Purity: >95.0%(GC)
Reference databases: ChEBI·ChemSpider·ECHA

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol
SMILES: C(COCCOCCOCCO)O
InChIKey: UWHCKJMYHZGTIT-UHFFFAOYSA-N

Rp 557.550,00

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Tetraethylene Glycol from TCI (product code T0099) is an ethylene glycol oligomer made of four oxyethylene units, with a hydroxyl group at each end. You can think of it as a "short PEG" with a defined chain length. It does two jobs in the laboratory. First, it is a building block for making linkers, crown ethers and other oligoethylene glycol derivatives. Second, it is a polar, high-boiling solvent used in many reactions and materials processes. It is listed in the Non-Heterocyclic Building Blocks category.

Chemists choose this material because every molecule has the same chain length. Polymeric polyethylene glycol always contains a spread of molecular weights, but tetraethylene glycol gives a linker with an exact, predictable spacing. That precision matters in molecular design and bioconjugation. The ether backbone makes the molecule soluble in water and polar solvents, keeps it flexible, and lets it coordinate cations. The two terminal hydroxyl groups can be functionalised one after the other. As a solvent, its low volatility and its ability to dissolve metal salts make it a common choice for the polyol method of nanoparticle synthesis.

In Indonesia, organic and medicinal chemistry laboratories use Tetraethylene Glycol to build oligoethylene glycol linkers and spacers for target molecules and conjugates. Materials science and nanotechnology groups at universities and research institutes use it as a high-boiling polyol solvent to prepare metal and metal oxide nanoparticles. Supramolecular chemistry researchers use it as a starting material for crown ethers and related host molecules. Teaching laboratories also find it useful for showing how chain length and ether functionality affect solubility and coordination.

TCI brochures (PDF)

Biomaterials Research Reagents 2025-02-19 · p. 20

Related TCI products

Linker and spacer synthesis: the fixed four-unit chain gives an exact distance between connected groups, and the two hydroxyl ends can be modified one at a time.
Bioconjugation research: the defined oligoethylene glycol chain improves water solubility and flexibility, and it avoids the molecular weight spread found in polymeric PEG reagents.
Crown ether and host molecule preparation: the ether oxygens along the chain can coordinate cations, so it is a logical precursor for macrocyclic and supramolecular structures.
Polyol-method nanoparticle synthesis: low volatility, a high boiling point and good solubility for metal salts make it a suitable reaction medium for preparing nanoparticles.
Oligoethylene glycol derivative synthesis: stepwise functionalisation of the terminal hydroxyl groups makes it possible to build tailored derivatives for molecular design and materials work.

Brand	TCI (product code T0099)
CAS number	112-60-7
Molecular formula	—
Purity	—
Category	Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes	as listed on the product page; please ask our team about available options
Physical form	liquid
Storage	keep tightly closed in a cool, dry, well-ventilated place

Store Tetraethylene Glycol in its original, tightly sealed container in a cool, dry, well-ventilated area, away from direct sunlight, heat sources and strong oxidising agents. Glycols can absorb moisture from the air, so close the container promptly after each use to protect the material's quality. Use clean, dry glass or compatible chemical-resistant containers when transferring it. Follow standard laboratory practice: wear safety glasses, gloves and a lab coat, avoid contact with skin and eyes, and work in a well-ventilated area or fume hood. Always read the supplier's Safety Data Sheet before use and dispose of waste according to local regulations.

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