Collection: Denaturation

Denaturation — covers chaotropic agents such as urea and thiourea, as well as ionic and zwitterionic detergents that disrupt hydrogen bonds and hydrophobic interactions in protein structures. These reagents are primary working tools in protein folding and unfolding research in biochemistry laboratories.

Chaotropic agents such as urea are used by biochemistry researchers to dissolve and denature proteins before electrophoresis or purification of inclusion-body proteins, while zwitterionic detergents and alkyl sulfates are used to dissolve membrane proteins without excessively damaging secondary structure. This reagent group also plays a role in sample preparation for proteomic analysis and in refolding studies of recombinant proteins.

Example products in this collection: TCI U0077 57-13-6 Urea [for Biochemical Research], TCI C2263 124-03-8 Ethylhexadecyldimethylammonium Bromide [for Biochemical Research], TCI T4197 1119-97-7 Tetradecyltrimethylammonium Bromide [for Biochemical Research], TCI D3860 14933-08-5 Dodecyldimethyl(3-sulfopropyl)ammonium Hydroxide Inner Salt [for Biochemical Research], TCI T3071 50996-85-5 Tris Dodecyl Sulfate [for Biochemical Research], TCI D4246 15163-36-7 Decyldimethyl(3-sulfopropyl)ammonium Hydroxide Inner Salt [for Biochemical Research], TCI T2835 62-56-6 Thiourea [for Biochemical Research], TCI D4247 15178-76-4 Dimethyl(n-octyl)(3-sulfopropyl)ammonium Hydroxide Inner Salt [for Biochemical Research].

Pay attention to the purity grade for biochemical research (grade for biochemical research), the type of detergent charge (ionic, nonionic, or zwitterionic), and the critical micelle concentration that suits the protocol requirements. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories at the same level under Biochemistry & Biological Reagents, often used together in a single laboratory workflow:

• Pharmaceutical Research Reagents (for Experimental Use)
• Amino Acids
• Carbohydrates
• Lipids
• Antibiotics
• Enzymes, Enzyme Inhibitors, Enzyme Substrates

This collection is further divided into 2 more specific groups:

• Detergents [Denaturation]
• Chaotropic Agents

Back to Biochemistry & Biological Reagents. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.