Collection: Protected Nucleosides [Nucleic Acid Synthesis]

Protected Nucleosides [Nucleic Acid Synthesis] — compiles nucleosides with benzoyl protecting groups on the nitrogen bases and silyl or trityl groups at the hydroxyl positions of ribose/deoxyribose. These protecting groups prevent unwanted side reactions during the stepwise stages of oligonucleotide synthesis.

These protected nucleosides are used by molecular biology and nucleic acid chemistry researchers as building blocks in solid-phase synthesis of oligonucleotides and synthetic DNA/RNA, where the protecting groups are selectively removed in the final stage. Combinations such as dimethoxytrityl on the 5'-hydroxyl group and benzoyl on the amino bases allow control of regioselectivity during repeated coupling cycles.

Example products in this collection: TCI B3631 69304-43-4 N4-Benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)cytidine, TCI D3566 40615-39-2 5'-O-(4,4'-Dimethoxytrityl)thymidine, TCI B3460 58463-04-0 N6-Dibenzoyladenosine 2',3'-Dibenzoate, TCI D5997 40733-27-5 3'-O-[tert-Butyl(dimethyl)silyl]thymidine, TCI B3103 64325-78-6 N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine, TCI I0697 68892-41-1 N2-Isobutyryl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyguanosine, TCI B3102 4836-13-9 N4-Benzoyl-2'-deoxycytidine, TCI I0699 64350-24-9 N2-Isobutyrylguanosine.

Pay attention to the position and type of protecting groups (base versus sugar), the hydrate or anhydrous form, and purity, as these affect coupling efficiency and ease of deprotection in oligonucleotide synthesis. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other parallel categories under Nucleosides, often used together in one laboratory workflow:

• Nucleoside Analogs
• Nucleobases and their Analogs
• Nucleotides
• Nucleotide Analogs
• NAD(P)(H) and Analogs
• Oxidoreductase Coenzymes [Nucleosides, Nucleotides, Oligonucleotides]

Back to Nucleosides. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team, the official TCI Japan distributor in Indonesia, for availability checks and lead times directly from Japan.