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CAS 70-34-8

2,4-Dinitrofluorobenzene [for HPLC Labeling] TCI A5512

2,4-Dinitrofluorobenzene [for HPLC Labeling] TCI A5512

Chemical Identity

CAS No.
70-34-8
PubChem
CID 6264·SID 87563159
Formula
C6H3FN2O4
Molecular weight
186.10 g/mol
Purity
>99.0%(GC)
Reference databases
ChEBI·ChemSpider·ECHA·Wikipedia
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
1-fluoro-2,4-dinitrobenzene
SMILES
C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])F
InChIKey
LOTKRQAVGJMPNV-UHFFFAOYSA-N
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2,4-Dinitrofluorobenzene is a chemical compound widely used in analytical chemistry for derivatization processes. It plays a crucial role in laboratories by enabling the modification of molecular structures of other compounds, which enhances their detectability and identification through advanced techniques like HPLC. This reagent is particularly valuable in quantitative and qualitative analysis, offering a reliable means to label and track compounds during complex chemical analyses. Its application spans various fields, including organic chemistry and pharmaceutical research, where precise detection is essential.

The compound is favored for its chemical stability and reactivity towards a wide range of organic substances. Its molecular structure facilitates substitution reactions at aromatic positions, making it highly suitable for derivatization applications. The compound’s resistance to degradation ensures consistent performance and reliability in laboratory settings. Additionally, its non-volatile nature contributes to its effectiveness in chromatographic methods, where stability and solubility are critical factors. These properties make it a preferred choice for analytical chemists seeking accurate and reproducible results.

In Indonesian laboratories, 2,4-Dinitrofluorobenzene is commonly used in analytical research, especially in organic chemistry and pharmaceutical studies. Its role in HPLC labeling makes it a key reagent for quantitative analysis, supporting both academic and industrial research. Due to its availability and performance, it is a standard component in laboratories focused on chemical analysis and compound identification.

Advantages (TCI brochure)

  • Reacts easily with an amino group to form the corresponding 2,4-dinitrophenylamine derivative
  • Derivative is stable and reaches the detector without decomposition in reversed phase HPLC
  • Excellent chromatogram obtained at 254 nm, a wavelength generally used for UV detection

TCI brochures (PDF)

  • HPLC Labeling: This compound is ideal for labeling compounds to enhance their detectability in high-performance liquid chromatography, allowing for more accurate identification and quantification.
  • Organic Chemistry Research: It is frequently used in derivatization reactions to modify molecular structures, aiding in the analysis of complex organic mixtures.
  • Pharmaceutical Analysis: Its reactivity and stability make it suitable for analyzing pharmaceutical compounds, ensuring precise detection in drug development and quality control.
  • Environmental Monitoring: It supports the analysis of environmental samples by enabling the detection of trace organic pollutants through derivatization techniques.
  • Food Safety Testing: It is used in the identification of organic compounds in food samples, contributing to safety and quality assurance in the food industry.

From the TCI brochure

  • Alkylamines (as 2,4-dinitrophenyl derivatives)
  • Amino acids
  • Aminoglycosides

Brand TCI
CAS number 70-34-8
Molecular formula —
Purity —
Category Analytical Chemistry > Analytical Reagents > Derivatization Reagents
Pack sizes Available in various quantities as per standard laboratory requirements
Physical form Solid
Storage Store in a cool, dry place away from direct sunlight

Data from the TCI brochure

Panjang gelombang deteksi UV254 nm (Kolom Kaseisorb LC C4-60-5 4.6 mm I.D.x150 mm; CH3CN/H2O = 45/55; 1 mL/min)

Source: TCI brochure A1096 (2026-03-10)

This compound should be stored in a cool, dry place, away from direct sunlight and sources of heat. It is recommended to use airtight containers to prevent exposure to moisture and air, which could affect its stability. Due to its chemical reactivity, it should be handled with care, using appropriate personal protective equipment such as gloves and safety goggles. It is important to ensure that storage areas are well-ventilated to minimize any potential risks associated with its use. Proper labeling of storage containers is essential to maintain safety and prevent accidental exposure. Laboratories should follow standard chemical handling protocols to ensure safe and effective use of this reagent.

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