(R)-(-)-DBD-Py-NCS is a derivatization reagent widely used in advanced liquid chromatography (HPLC) analysis. It serves as a labeling agent that enhances the detection and identification of compounds in complex samples. This reagent is essential in analytical chemistry for improving the clarity of detection results through specific spectral or reactive changes. Its role in the laboratory is critical for achieving accurate and sensitive analytical outcomes.
The key properties of (R)-(-)-DBD-Py-NCS include its ability to react selectively with target compounds, making it a preferred choice for precise identification. Its complex chemical structure allows for efficient and selective reactions, ensuring reliable results. The stability and reactivity of this reagent contribute to its consistency and reliability in analytical processes. These characteristics make it a trusted tool for high-precision laboratory work.
In Indonesian laboratories, (R)-(-)-DBD-Py-NCS is commonly used in scientific research, product quality testing, and environmental analysis. Its availability supports faster analysis processes and improves the quality of research outcomes. This reagent is particularly relevant for institutions and industries requiring accurate and measurable chemical analysis. Its application is essential in maintaining high standards of analytical work in the region.
Advantages (TCI brochure)
- Reacts with amino or mercapto groups bonded to an asymmetric carbon, forming diastereomers
- Diastereomers separated by reversed phase HPLC with fluorescence detection
- Enantiomeric reagents commercially available, so elution order can be changed; reported use in Edman degradation
TCI brochures (PDF)
- HPLC Labeling Reagents 2026-03-10 · p. 3
Related TCI products
- TCI A5595 98358-90-8 DBD-F [=4-(N,N-Dimethylaminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole] [for HPLC Labeling]
- TCI A5593 29270-56-2 NBD-F (=4-Fluoro-7-nitro-2,1,3-benzoxadiazole) [for HPLC Labeling]
- TCI A5592 10199-89-0 NBD-Cl (=4-Chloro-7-nitro-2,1,3-benzoxadiazole) [for HPLC Labeling]
- TCI A5569 163927-32-0 (S)-(+)-DBD-Py-NCS [=(S)-(+)-4-(N,N-Dimethylaminosulfonyl)-7-(3-isothiocyanatopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [for HPLC Labeling]
- TCI A5558 156153-43-4 DBD-COCl [=4-(N,N-Dimethylaminosulfonyl)-7-(N-chloroformylmethyl-N-methylamino)-2,1,3-benzoxadiazole] [for HPLC Labeling]
- TCI A5597 91366-65-3 ABD-F [=4-(Aminosulfonyl)-7-fluoro-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for Determination of Thiols]
- Scientific research in analytical chemistry benefits from this reagent's ability to enhance detection accuracy and specificity in complex sample analysis.
- Product quality testing relies on its capacity to improve the sensitivity and clarity of chromatographic results, ensuring reliable data for quality control.
- Environmental analysis utilizes its selective reactivity to identify trace compounds in samples, supporting accurate pollution monitoring and assessment.
- Pharmaceutical development employs this reagent for compound identification and quantification in drug analysis, ensuring compliance with regulatory standards.
- Forensic and toxicological studies benefit from its role in detecting and analyzing substances in biological and environmental matrices with high precision.
From the TCI brochure
- Optical purity determination of amines (1-phenylethylamine)
- Thiols (thiopronine, as printed)
| Brand | TCI |
|---|---|
| CAS number | 163927-31-9 |
| Molecular formula | — |
| Purity | — |
| Category | Analytical Chemistry > Analytical Reagents > Derivatization Reagents |
| Pack sizes | Available in standard laboratory quantities as per supplier specifications |
| Physical form | Solid or powder, depending on formulation |
| Storage | Store in a cool, dry place away from light and moisture |
Data from the TCI brochure
| Excitation wavelength | 460 nm (Fluorescence detection) |
|---|---|
| Emission wavelength | 550 nm (Fluorescence detection) |
| Detection limit (S/N = 2) | 0.5 pmol (Thiopronine) |
| Mobile phase | CH3CN / H2O = 40 / 60 containing 0.05% TFA (Kaseisorb LC ODS Super, ambient, 1 mL/min) |
| Reaction | 5 mM reagent, 1 mM amine, 2% triethylamine (CH3CN-H2O, 55 C, 10 min) |
Source: TCI brochure A1096 (2026-03-10)
This reagent should be stored in a cool, dry environment, away from direct light and moisture to maintain its stability and effectiveness. It is recommended to use airtight containers to prevent exposure to air and contaminants. In laboratory settings, it should be handled with appropriate personal protective equipment to ensure safety. Due to its chemical nature, it should be kept in a secure location, away from incompatible substances. Regular monitoring of storage conditions is advised to ensure optimal performance and safety during use. Proper labeling and documentation of storage conditions are essential for maintaining compliance with laboratory safety protocols.
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Product Categories
- Analytical ReagentsDerivatization ReagentsHPLC Derivatization Reagents
- HPLCHPLC Derivatization ReagentsFluorescence Detection Labeling Reagents (for Amino Groups) [HPLC Derivatization Reagents]
- HPLCHPLC Derivatization ReagentsFluorescence Detection Labeling Reagents (for Thiol Groups) [HPLC Derivatization Reagents]
![163927-31-9 (R)-(-)-DBD-Py-NCS [=(R)-(-)-4-(N,N-Dimethylaminosulfonyl)-7-(3-isothiocyanatopyrrolidin-1-yl)-2,1,3-benzoxadiazole] [for HPLC Labeling] - AMI Scientific](http://amiscientific.com/cdn/shop/files/TCI2510A5568_362479bf-2985-458e-84d4-983894568fca.jpg?v=1772176822&width=1445)