• 163927-29-5 (R)-(-)-NBD-Py-NCS [=(R)-(-)-4-(3-Isothiocyanatopyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] - AMI Scientific
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TCI

CAS 163927-29-5

(R)-(-)-NBD-Py-NCS [=(R)-(-)-4-(3-Isothiocyanatopyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] TCI A5577

(R)-(-)-NBD-Py-NCS [=(R)-(-)-4-(3-Isothiocyanatopyrrolidin-1-yl)-7-nitro-2,1,3-benzoxadiazole] [HPLC Labeling Reagent for e.e. Determination] TCI A5577

Chemical Identity

Other names
(R)-(-)-NBD-Py-NCS
CAS No.
163927-29-5
PubChem
CID 16218431·SID 87563194
Formula
C11H9N5O3S
Molecular weight
291.29 g/mol
Purity
>98.0%(HPLC)
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
7-[(3R)-3-isothiocyanatopyrrolidin-1-yl]-4-nitro-2,1,3-benzoxadiazole
SMILES
C1CN(C[C@@H]1N=C=S)C2=CC=C(C3=NON=C23)[N+](=O)[O-]
InChIKey
CHKCHHTYBXOUKH-SSDOTTSWSA-N
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(R)-(-)-NBD-Py-NCS is a specialized chemical reagent used in analytical laboratories for determining enantiomeric excess (e.e.) of optically active compounds. This reagent plays a crucial role in analytical chemistry by enabling the differentiation and quantification of chiral molecules. It is widely applied in both qualitative and quantitative analysis, particularly in the field of pharmaceutical research and development. Its utility lies in its ability to react selectively with one enantiomer, allowing for accurate measurement of optical purity. This makes it an essential tool for researchers working with chiral compounds and isotope labeling techniques.

The reagent's high fluorescence properties make it an ideal choice for High-Performance Liquid Chromatography (HPLC) applications. Its fluorescent labeling capability enhances detection sensitivity and accuracy, especially when analyzing complex mixtures. Additionally, the reagent is stable under controlled conditions and can be easily incorporated into various analytical procedures. These characteristics ensure reliable and reproducible results, making it a preferred option for laboratories requiring precise optical analysis.

In Indonesian laboratories, (R)-(-)-NBD-Py-NCS is commonly used in scientific research, drug development, and chemical quality analysis. Its accuracy and reliability make it a valuable asset in analytical workflows. Its application is particularly relevant in pharmaceutical and chemical industries where the analysis of chiral compounds is essential for product development and quality control.

Advantages (TCI brochure)

  • Reacts with amino groups bonded to an asymmetric carbon, forming diastereomers
  • Both (R) and (S) reagent isomers are commercially available
  • Enantiomer choice can change elution order of diastereomers
  • Allows minor enantiomer to be eluted first and quantified with high precision

TCI brochures (PDF)

Related TCI products

  • Pharmaceutical research for enantiomer analysis due to its ability to label and detect chiral compounds accurately.
  • Quality control in chemical manufacturing to ensure product purity and consistency through optical analysis.
  • Academic research in analytical chemistry for studying molecular structure and isomer separation techniques.
  • Drug development processes to assess the optical purity of active pharmaceutical ingredients.
  • Environmental testing for identifying and quantifying chiral pollutants in complex matrices.

From the TCI brochure

  • Optical purity determination of chiral amines
  • Reports of application to Edman Degradation

Brand TCI
CAS number 163927-29-5
Molecular formula —
Purity —
Category Analytical Chemistry > Analytical Reagents > Derivatization Reagents
Pack sizes Available in various quantities as per supplier specifications
Physical form Solid or liquid, depending on the specific product formulation
Storage Store in a cool, dry place away from light and moisture

Data from the TCI brochure

Excitation wavelength488 nm (Fluorescence detection of diastereomer thioureas)
Emission wavelength590 nm (Fluorescence detection of diastereomer thioureas)
ColumnKaseisorb LC ODS 2000, 4.6 mm I.D. x 150 mm (Chromatogram of amino acids)
Mobile phaseCH3CN / H2O = 40 / 60 containing 0.05% TFA; 1 mL/min (Temperature 30 ºC)

Source: TCI brochure A1096 (2026-03-10)

This reagent should be stored in a cool, dry environment, away from direct sunlight and sources of heat. It is recommended to use airtight containers to prevent exposure to moisture and air, which may affect its stability. Proper labeling of storage containers is essential to ensure safe handling and prevent cross-contamination. In a laboratory setting, it is important to follow standard safety protocols, including the use of personal protective equipment when handling. The reagent should not be exposed to incompatible substances, and storage conditions should be monitored regularly to maintain its integrity and effectiveness.

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Analytical Chemistry

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