DBD-NCS [=4-(N,N-Dimethylaminosulfonyl)-7-isothiocyanato-2,1,3-benzoxadiazole] [for HPLC Labeling and Edman Degradation] TCI A5575

Chemical Identity

Other names: DBD-NCS
CAS No.: 147611-81-2
PubChem: CID 127043·SID 87563192
Formula: C9H8N4O3S2
Molecular weight: 284.3 g/mol

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 7-isothiocyanato-N,N-dimethyl-2,1,3-benzoxadiazole-4-sulfonamide
SMILES: CN(C)S(=O)(=O)C1=CC=C(C2=NON=C12)N=C=S
InChIKey: SUOZAUUDBKHLHQ-UHFFFAOYSA-N

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DBD-NCS, also known as 4-(N,N-Dimethylaminosulfonyl)-7-isothiocyanato-2,1,3-benzoxadiazole, is a chemical reagent widely used in analytical chemistry for derivatization processes. It plays a crucial role in laboratories by enabling the modification of target compounds to enhance their detectability in analytical techniques such as HPLC and Edman Degradation. This reagent is particularly important for the structural analysis of proteins, where it facilitates the identification of amino acid sequences through chemical labeling. Its application extends to various analytical workflows where precision and sensitivity are essential.

The chemical properties of DBD-NCS make it a preferred choice in laboratory settings. It exhibits stability and reactivity, allowing it to interact effectively with a wide range of organic compounds. Its molecular structure enables it to form stable derivatives, which are essential for accurate detection in chromatographic methods. Additionally, DBD-NCS demonstrates good reactivity towards various substrates, making it versatile for different analytical applications. These characteristics ensure reliable results and make it a valuable tool in analytical chemistry.

In Indonesian laboratories, DBD-NCS is commonly used in research and quality testing of chemical substances. It is an essential component in the analysis of complex mixtures and is frequently employed in academic and industrial settings. Its role in enhancing detection sensitivity and selectivity makes it a key reagent for analytical chemists working on protein structure analysis and other derivatization-based techniques. Its use supports the advancement of analytical methods in both educational and research environments.

Advantages (TCI brochure)

Reacts easily with amino groups to form a thiourea derivative
Reagent itself does not fluoresce and is stable as crystal and in solution
Thiourea derivative stays intact under reversed phase HPLC
Detection limit in the sub-picomol order (S/N = 3)

TCI brochures (PDF)

HPLC Labeling Reagents 2026-03-10 · p. 3

Related TCI products

HPLC Labeling is enhanced by DBD-NCS, which allows for the detection of analytes with improved sensitivity and resolution, making it ideal for complex sample analysis.
Edman Degradation benefits from DBD-NCS as it facilitates the sequential determination of amino acid residues, essential for protein sequence analysis.
Derivatization Reagents are critical in modifying compounds for better chromatographic performance, and DBD-NCS provides a reliable solution for this purpose.
Structural Analysis of Proteins relies on DBD-NCS to provide accurate and reproducible results in amino acid sequencing.
Chemical Modification of Target Compounds is made more efficient by DBD-NCS, which enables the formation of stable derivatives for detection in analytical methods.

From the TCI brochure

Amino acid sequence analysis (Edman Degradation) by binding the N-terminal amino acid of peptides or proteins, followed by acid treatment

Brand	TCI
CAS number	147611-81-2
Molecular formula	—
Purity	—
Category	Analytical Chemistry > Analytical Reagents > Derivatization Reagents
Pack sizes	—
Physical form	—
Storage	Store in a cool, dry place away from light and moisture

Data from the TCI brochure

Excitation wavelength	384 nm (Fluorescence detection of DBD-CA derivative)
Emission wavelength	520 nm (Fluorescence detection of DBD-CA derivative)
Detection limit	order of sub-picomol (S/N = 3)

Source: TCI brochure A1096 (2026-03-10)

DBD-NCS should be stored in a cool, dry place away from direct light and moisture to maintain its chemical stability. It is recommended to use airtight containers to prevent exposure to air and humidity, which could affect its reactivity. Proper labeling of storage containers is essential to ensure safe handling and prevent accidental contamination. Laboratory personnel should wear appropriate personal protective equipment when handling this reagent to minimize exposure. Due to its chemical nature, it should be kept away from incompatible substances to avoid any potential reactions. Regular inspection of storage conditions is advised to ensure the reagent remains in optimal condition for analytical use.

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Analytical Chemistry

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