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Description
TCI C0427 Lanosterol (CAS 79-63-0) is a triterpenoid sterol that occupies a central position in the eukaryotic sterol biosynthesis pathway. It serves as a substrate and reference compound in studies of sterol 14α-demethylase, the enzyme targeted by azole antifungal agents. Researchers also use it to examine membrane properties, mevalonate pathway intermediates, and lens protein aggregation. The powder should be kept tightly closed in a cool, dark, and dry place, and weighed with gloves and eye protection in a well-ventilated area.
Scientific References
Risley (2002). Cholesterol Biosynthesis: Lanosterol to Cholesterol. Journal of Chemical Educationdoi:10.1021/ed079p377
Shanmugam et al. (2015). Effect of lanosterol on human cataract nucleus. Indian Journal of Ophthalmologydoi:10.4103/0301-4738.176040
Tuck et al. (1991). Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors on sterol biosynthesis downstream of lanosterol.. Journal of Lipid Researchdoi:10.1016/s0022-2275(20)41987-x
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
