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Description
TCI D4250 1,2-Dioleoyl-sn-glycero-3-phosphocholine (CAS 4235-95-4), more widely known as DOPC, is a synthetic phospholipid built on a glycerol backbone carrying two unsaturated oleic acid chains and a phosphocholine head group. It has become one of the most important lipids in drug delivery research because of its ability to spontaneously form lipid bilayers and vesicles in water. In the laboratory, DOPC is used to assemble liposomes, model membranes, and a wide range of nanocarriers designed to transport active compounds toward specific biological targets.
The advantage of DOPC comes from the unsaturation of its oleate chains, which adopt a cis configuration. These double bonds introduce a kink in the acyl chains, so the resulting bilayer sits in the liquid-disordered phase at common laboratory working temperatures. The membranes formed this way are flexible, readily fusogenic, and very well suited to simulating the dynamic character of biological membranes. The zwitterionic phosphocholine head group gives the vesicle surface a charge-neutral character, so unintended interactions with proteins and nucleic acids can be minimised. The point requiring attention is that the unsaturated chains demand careful handling.
In Indonesian laboratories, DOPC of this grade is typically found in pharmaceutical development groups, formulation laboratories, and university research units working on drug delivery systems. It serves as the base lipid for preparing liposomes and model membranes in studies of encapsulation, membrane behaviour, and targeted carrier design. Because the material supports both routine formulation work and more exploratory membrane biophysics, it fits research programmes at academic institutions as well as pharmaceutical and biotechnology development settings.
Laboratory Applications
- Liposome preparation: DOPC forms bilayer vesicles spontaneously in aqueous media, making it a dependable base lipid for building liposomal carriers that encapsulate active compounds.
- Model membrane construction: the liquid-disordered bilayer formed by DOPC reproduces the flexible, dynamic character of biological membranes, supporting realistic membrane behaviour studies in vitro.
- Nanocarrier development: DOPC serves as a structural lipid in nanoscale carriers designed to transport active compounds toward defined biological targets within drug delivery research.
- Drug delivery systems (DDS) research: its established role as a core phospholipid makes DOPC a standard component for formulation studies exploring encapsulation and release behaviour.
- Membrane interaction studies: the charge-neutral zwitterionic phosphocholine surface minimises unintended binding of proteins and nucleic acids, giving cleaner interaction experiments with fewer artefacts.
Specifications
- Brand: TCI
- CAS Number: 4235-95-4
- Chemical name: 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC)
- Catalogue reference: D4250
- Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
- Pack sizes: available in the packaging options offered by the manufacturer for this catalogue item
Handling and Storage
Because DOPC contains unsaturated oleate chains, it should be handled with care and kept under the storage conditions specified by the manufacturer on the product label and safety data sheet. Store the material in its original tightly closed container, protected from air, moisture, light, and heat, and keep it in a cool place designated for lipid reagents. Allow sealed containers to equilibrate to room temperature before opening to limit condensation. Handle the material in a clean laboratory area with adequate ventilation, using gloves, safety glasses, and a laboratory coat, and use clean dry glassware or compatible solvent-resistant labware when preparing solutions. Minimise repeated opening of the stock container and follow institutional procedures for chemical waste disposal.
