1,2-Dimyristoyl-sn-glycero-3-phosphocholine TCI D3924

Name: TCI D3924 18194-24-6 1,2-Dimyristoyl-sn-glycero-3-phosphocholine
Brand: TCI
SKU: TCI2510D392424355
Price: 2952600.0 IDR
Availability: InStock

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Berat 200mg 1g

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Description

TCI D3924, 1,2-Dimyristoyl-sn-glycero-3-phosphocholine — more commonly known by the abbreviation DMPC — is a synthetic phospholipid built from two saturated fourteen-carbon myristic acid chains esterified to a glycerol backbone in the sn configuration, together with a phosphocholine head group. In the laboratory it functions as a building block for artificial membranes: it forms liposomes, unilamellar vesicles, mixed micelles, and supported lipid bilayers that serve as simplified models of living cell membranes. Its role is especially central in research on drug delivery systems.

The main characteristic that makes DMPC such a widely chosen lipid is its phase transition temperature, which is low among the saturated phosphatidylcholines because its acyl chains are relatively short. As a result, DMPC bilayers sit in the liquid-ordered phase at temperatures that are comfortable to work with on the bench, so hydration, extrusion, and sonication proceed more easily than with longer-chain lipids. Its phosphocholine head group is zwitterionic and overall neutral, so the vesicles formed carry a low surface charge and electrostatic interactions with active ingredients can be controlled deliberately rather than left to chance.

In Indonesian laboratories, DMPC is typically used in pharmaceutical development and drug discovery groups, in university research units, and in formulation laboratories that prepare liposomal carriers and membrane models. Because its handling temperature is convenient, it suits laboratories that prepare vesicles routinely without specialised high-temperature equipment. It is commonly ordered alongside other phospholipids for work on drug delivery systems, membrane biophysics, and the preparation of model bilayers for method development and teaching.

Laboratory Applications

Liposome preparation — DMPC hydrates and extrudes readily at convenient bench temperatures, making it a dependable base lipid for producing reproducible liposomal suspensions in formulation work.
Drug delivery system research — its neutral zwitterionic head group keeps vesicle surface charge low, so electrostatic interactions with active pharmaceutical ingredients can be controlled and studied systematically.
Supported lipid bilayer formation — the low phase transition temperature lets bilayers form and equilibrate on solid supports without heating steps that complicate membrane model experiments.
Unilamellar vesicle production — sonication and extrusion of DMPC proceed more easily than with longer-chain saturated lipids, giving laboratories a practical route to uniform vesicle populations.
Mixed micelle and membrane model studies — DMPC combines with other lipids and surfactants to build simplified models of living cell membranes for biophysical and mechanistic investigation.

Specifications

Brand: TCI
CAS number: 18194-24-6
Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
Product code: D3924
Pack sizes: available in the catalogue pack sizes offered by TCI for this product code
Storage: store as directed on the manufacturer's label for synthetic phospholipid reagents

Handling and Storage

Synthetic phospholipids such as DMPC are normally kept cold and protected from moisture and air, following the storage conditions stated on the manufacturer's label and safety data sheet. Keep the material in its original tightly closed container, or transfer it to a clean, dry, chemically compatible vessel with a secure closure, and allow sealed containers to reach room temperature before opening to limit condensation. Handle the powder in a well-ventilated area or fume hood, wear a laboratory coat, safety glasses, and suitable gloves, avoid generating dust, and prepare stock solutions using clean glassware and appropriate solvents. Label all prepared vesicle suspensions clearly and consult the safety data sheet before first use.