1,2-Distearoyl-sn-glycero-3-phosphocholine TCI D3926

Name: TCI D3926 816-94-4 1,2-Distearoyl-sn-glycero-3-phosphocholine
Brand: TCI
SKU: TCI2510D392624359
Price: 3011400.0 IDR
Availability: InStock

Rp 3.011.400,00

Sale Sold out

Shipping calculated at checkout.

Berat 200mg 1g

Pembayaran hanya melalui request quotation dan dilakukan setelah tim kami menghubungi Anda. Mohon cantumkan nomor WhatsApp aktif untuk konfirmasi pesanan & pembuatan invoice. Estimasi pengiriman 4-5 minggu setelah pembayaran.

Description

TCI D3926, 1,2-Distearoyl-sn-glycero-3-phosphocholine (CAS 816-94-4), commonly abbreviated as DSPC, is a long-chain saturated phospholipid built on an sn-configured glycerol backbone carrying two eighteen-carbon stearoyl acyl groups and a zwitterionic phosphocholine head group. In the laboratory, DSPC is recognised as a principal structural lipid in a wide range of modern drug-carrier formulations, from classical liposomes through to lipid nanoparticles used for nucleic acid delivery. Its role is to provide a robust, tightly packed and leakage-resistant membrane framework, so that the active substance remains encapsulated until the particle reaches its intended target.

The property that makes DSPC such a widely preferred choice is its acyl chain length, which places the phase transition temperature well above body temperature. As a result, the bilayer remains in a rigid gel phase under physiological conditions. This rigidity lowers membrane permeability, slows the leakage of dissolved solutes, and improves particle stability during storage. Because its chains are fully saturated, DSPC is also comparatively resistant to oxidation when set against unsaturated phospholipids — an important advantage for formulations that must remain stable over long periods. The zwitterionic phosphocholine head group contributes the familiar bilayer-forming behaviour expected of a phosphatidylcholine.

In Indonesian laboratories, DSPC is typically used in pharmaceutical development and drug discovery research groups working on drug delivery systems (DDS). It is handled in university research laboratories, pharmaceutical formulation units, and institutional research centres where liposome and lipid nanoparticle preparation is part of routine experimental work. Such laboratories generally value a structural lipid that behaves consistently between batches, tolerates ambient conditions during handling, and supports formulation work that must be repeated and reproduced over an extended research programme.

Laboratory Applications

Liposome preparation — DSPC serves as the main bilayer-forming lipid, providing a rigid gel-phase membrane that holds encapsulated actives securely inside the vesicle during handling and storage.
Lipid nanoparticle formulation for nucleic acid delivery — the saturated eighteen-carbon chains supply the structural helper-lipid framework required to build stable particles that protect their nucleic acid cargo.
Controlled-release drug carrier development — its low membrane permeability slows solute leakage, making it suitable for studies where the release profile of an encapsulated compound must be deliberately restrained.
Long-term stability studies of lipid formulations — full chain saturation makes DSPC comparatively resistant to oxidation, so it suits formulation work that must remain reliable across extended storage periods.
Drug delivery systems (DDS) research and screening — as a well-characterised structural phosphatidylcholine, it gives formulation scientists a consistent membrane baseline against which other lipid components can be compared.

Specifications

Brand: TCI
Catalogue number: D3926
CAS number: 816-94-4
Chemical name: 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC)
Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
Pack sizes: available in the standard TCI catalogue pack sizes; please confirm the required size when ordering
Storage: store according to the conditions stated on the manufacturer's label and safety data sheet

Handling and Storage

Store the container tightly closed in a cool, dry place, following the storage temperature stated on the manufacturer's label and safety data sheet for this product. Keep the material in its original container or in a clean, well-sealed glass vessel, protected from moisture, direct sunlight and sources of heat. As a lipid intended for formulation work, it should be handled in a clean working area to avoid contamination, and containers should be allowed to reach room temperature before opening to limit condensation. Wear standard laboratory personal protective equipment — laboratory coat, safety glasses and suitable gloves — and handle powders with care to avoid raising dust. Always consult the manufacturer's safety data sheet before use, and dispose of residues and contaminated materials in accordance with applicable laboratory waste procedures.