1,2-Dimyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt TCI D3946

Name: TCI D3946 200880-40-6 1,2-Dimyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt
Brand: TCI
SKU: TCI2510D394624384
Price: 9976050.0 IDR
Availability: InStock

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Berat 1g

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Description

1,2-Dimyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt, commonly abbreviated as DMPG sodium salt, is a negatively charged synthetic phospholipid built from two fourteen-carbon myristoyl acyl chains and a polar glycerophosphoglycerol head group. In the laboratory it serves as a key component in the assembly of liposomes, lipid vesicles, and a wide range of drug delivery systems. Pharmaceutical researchers use it to control the surface charge of carrier particles, improve colloidal stability, and study the interactions between lipid carriers and proteins, nucleic acids, and cell membranes during formulation development research.

The characteristics that make this material a preferred choice begin with the anionic charge contributed by the phosphoglycerol group, which provides electrostatic repulsion between vesicles so that liposome suspensions do not aggregate easily. The saturated and uniform myristoyl chains produce bilayers with sharp, predictable phase transition behaviour, making experiments straightforward to repeat and to compare across batches. Because the chains are saturated, the material is also more resistant to oxidation than phospholipids carrying unsaturated chains. When combined with neutral phospholipids such as the phosphatidylcholine class, it allows researchers to tune bilayer composition in a controlled manner.

In Indonesian laboratories, DMPG sodium salt is typically used in pharmaceutical formulation groups, university research centres, and drug delivery development units that prepare liposomal and vesicle-based carriers. It is generally handled in small, carefully weighed quantities as part of defined lipid mixtures, then hydrated or dissolved according to the chosen preparation protocol. Its reproducible behaviour makes it well suited to teaching laboratories and research programmes where consistent results across repeated preparations are required.

Laboratory Applications

Liposome preparation — the anionic head group supplies electrostatic repulsion that keeps vesicle suspensions dispersed and reduces the tendency of liposomes to aggregate during storage and handling.
Drug delivery system development — researchers incorporate this phospholipid to adjust the surface charge of carrier particles, which influences colloidal stability and the overall behaviour of the formulation.
Lipid bilayer and membrane model studies — the uniform saturated myristoyl chains give sharp, predictable phase transition behaviour, making it suitable for controlled investigations of bilayer properties.
Lipid carrier interaction research — it is used to examine how lipid carriers interact with proteins, nucleic acids, and cell membranes under defined and reproducible experimental conditions.
Formulation development and optimisation — combining it with neutral phospholipids such as the phosphatidylcholine class lets researchers tune bilayer composition systematically across successive formulation trials.

Specifications

Brand: TCI
Product code: D3946
CAS number: 200880-40-6
Chemical name: 1,2-Dimyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) Sodium Salt
Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
Pack sizes: available in the manufacturer's standard research packaging; please refer to the listed pack options

Handling and Storage

Store this phospholipid in its original tightly closed container, kept cold and protected from light and moisture in line with the manufacturer's stated storage conditions on the product label. Suitable containers are the supplied glass vial or an equivalent chemically resistant, well-sealed vessel; avoid leaving the material exposed to open air. Although the saturated myristoyl chains give better oxidation resistance than unsaturated phospholipids, the material should still be handled promptly and returned to storage after weighing. Allow containers to reach room temperature before opening to limit moisture condensation. Work in a well-ventilated area, wear a laboratory coat, gloves, and eye protection, and follow the safety data sheet together with your institution's standard laboratory practices.