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Description
TCI D5648, catalogued under CAS number 200880-42-8, is 1,2-Dioctadecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) Sodium Salt, commonly known as DSPG sodium salt. It is a negatively charged synthetic phospholipid carrying two saturated stearoyl acyl chains of eighteen carbon atoms each. The material belongs to the family of reagents used in drug delivery system research and serves as a key component in the preparation of liposomes, lipid vesicles, and lipid nanoparticles in pharmaceutical laboratories. Its role is to supply a negative surface charge together with structural stability to artificial membranes designed to carry active compounds.
The characteristics that make DSPG a widely preferred choice are the combination of its saturated stearoyl chains and its anionic phosphoglycerol head group. The long saturated chains produce a high phase transition temperature, so the bilayer remains rigid and tightly packed at both body temperature and storage temperature, and leakage of encapsulated substances can be suppressed. The absence of double bonds also makes this lipid far more resistant to oxidation than unsaturated phospholipids. Meanwhile, the phosphoglycerol head group provides a negative charge that generates electrostatic repulsion between vesicles, prevents aggregation, and allows researchers to tune the surface potential of their formulations.
In Indonesian laboratories, DSPG sodium salt is typically used in pharmaceutical development and drug discovery research settings, particularly by groups working on drug delivery systems. It is handled in formulation work where liposomes, lipid vesicles, and lipid nanoparticles are prepared and characterised, and where a defined anionic phospholipid of consistent synthetic origin is required. Because it is a synthetic material with a specified structure, it suits academic research groups, pharmaceutical formulation laboratories, and institutional research facilities that need reproducible results across preparations.
Laboratory Applications
- Liposome preparation — DSPG supplies the anionic bilayer component that gives vesicles a negative surface charge and the rigid, tightly packed membrane needed to retain encapsulated compounds.
- Lipid nanoparticle formulation — its saturated eighteen-carbon chains and defined synthetic structure allow reproducible nanoparticle assembly for drug delivery system research in pharmaceutical laboratories.
- Drug delivery system research — as a dedicated DDS reagent, it lets researchers build artificial membranes that carry active compounds while maintaining structural stability under storage and physiological temperature.
- Surface charge modulation studies — the anionic phosphoglycerol head group provides electrostatic repulsion between vesicles, so researchers can tune surface potential and prevent unwanted aggregation in suspensions.
- Lipid vesicle stability work — the absence of double bonds makes this phospholipid far more oxidation-resistant than unsaturated alternatives, supporting membrane studies that require chemically stable lipid components.
Specifications
- Brand: TCI
- CAS number: 200880-42-8
- Chemical name: 1,2-Dioctadecanoyl-sn-glycero-3-phospho-(1'-rac-glycerol) Sodium Salt (DSPG sodium salt)
- Category: Chemistry > Pharmaceutical Development and Drug Discovery Research Reagents > Drug Delivery Systems (DDS)
- Pack sizes: available in the pack sizes listed by the manufacturer for this catalogue number
- Storage note: store as directed on the product label; keep sealed and protected from moisture
Handling and Storage
Store TCI D5648 in its original tightly sealed container, following the storage conditions stated on the product label and in the manufacturer's documentation. As a phospholipid sodium salt, it should be kept sealed and protected from moisture, and containers should be allowed to reach ambient temperature before opening to limit condensation on the material. Handle the product in a clean, well-ventilated working area using standard laboratory personal protective equipment, including gloves, eye protection, and a laboratory coat. Use clean, dry spatulas and glass or otherwise chemically compatible vessels when weighing and transferring the powder, and reseal the container promptly after use. Consult the manufacturer's safety data sheet before handling, preparing solutions, or disposing of residues and contaminated materials.
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