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Description
Hinokitiol, also known as β-thujaplicin, is a naturally occurring compound of the tropolone class that was originally isolated from the wood of coniferous trees and is now supplied by TCI under catalogue code H0142. Its structure consists of an unusual aromatic seven-membered ring bearing adjacent hydroxyl and ketone groups together with an isopropyl substituent. In the laboratory, hinokitiol is used as a test compound in microbiology and chemical biology research, as a metal chelator, and as a reference material in the analysis of wood-extract-based products and personal care preparations.
The property that makes hinokitiol a preferred choice is the ability of the α-hydroxyketone group on the tropolone ring to bind metal ions strongly, forming stable chelate complexes. This same capability underlies its biological activity, including its role as a carrier of metal ions across membranes, a function that has been widely studied over the past decade. Hinokitiol is a crystalline solid with good solubility in organic solvents, which makes the preparation of stock solutions straightforward. The 1 g and 5 g pack sizes suit research work that generally consumes material on a milligram scale per experiment.
In Indonesia, hinokitiol attracts the attention of research laboratories working in the areas described above. The available pack sizes match the working pattern of academic and institutional groups that run experiments at milligram scale rather than consuming bulk quantities, so a single container typically supports an extended series of assays. Its behaviour as a crystalline solid readily dissolved in organic solvents also fits the standard stock-solution workflow used in local chemical biology and microbiology facilities.
Laboratory Applications
Microbiological research: hinokitiol serves as a defined test compound in screening and mechanism studies, giving investigators a naturally derived tropolone of known identity for comparative work.
Chemical biology studies: the compound is applied as a probe in cell-based and biochemical investigations, where its well-characterised structure supports reproducible interpretation of experimental observations.
Metal chelation work: the adjacent hydroxyl and ketone groups on the tropolone ring bind metal ions strongly, allowing hinokitiol to form stable chelate complexes for coordination experiments.
Metal ion transport research: its documented role as a carrier of metal ions across membranes makes it a reference compound for transport studies that have grown over the past decade.
Analytical reference use: hinokitiol acts as a reference material in the analysis of wood-extract-based products and personal care preparations, supporting identification and comparison against sample components.
Specifications
Brand: TCI, supplied under catalogue code H0142
CAS number: 499-44-5
Category: Chemistry > Building Blocks > Non-Heterocyclic Building Blocks
Pack sizes: 1 g and 5 g
Physical form: crystalline solid with good solubility in organic solvents
Storage note: keep in the original closed container under the conditions indicated on the supplied product label
Handling and Storage
Store hinokitiol in its original tightly closed container, protected from moisture and direct light, and follow the storage conditions stated on the manufacturer's label and safety data sheet. Amber glass vials or the original packaging are suitable for the solid, while prepared organic stock solutions should be kept in sealed, solvent-compatible containers and clearly labelled with concentration and preparation date. Weigh and transfer the crystalline material in a fume hood using clean, dry spatulas to avoid contamination and moisture uptake. Wear a laboratory coat, safety glasses, and chemically resistant gloves when handling the compound, and consult the safety data sheet before first use and for disposal guidance.
