N,N'-(Naphthalene-1,5-diyl)bis[2-(aminooxy)acetamide] TCI N1160

Chemical Identity

CAS No.: 1166232-68-3
PubChem: CID 101467493·SID 468592488
Formula: C14H16N4O4
Molecular weight: 304.30 g/mol
Purity: >95.0%(HPLC)

Full identifiers (IUPAC, SMILES, InChIKey)

IUPAC: 2-aminooxy-N-[5-[(2-aminooxyacetyl)amino]naphthalen-1-yl]acetamide
SMILES: C1=CC2=C(C=CC=C2NC(=O)CON)C(=C1)NC(=O)CON
InChIKey: MLWDZDBSRKXTQH-UHFFFAOYSA-N

Rp 3.207.750,00

~~Rp 2.258.550,00~~ Rp 3.207.750,00

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Berat 100mg

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N,N'-(Naphthalene-1,5-diyl)bis[2-(aminooxy)acetamide] is a chemical compound widely used in scientific research, particularly in the fields of chemical biology and conjugation chemistry. This compound plays a crucial role in laboratory settings by enabling the formation of stable molecular linkages through its unique structural properties. Its application is essential in the development of new compounds and in biochemical studies where precise molecular interactions are required. The compound’s ability to participate in click chemistry reactions makes it a valuable tool for researchers aiming to create complex molecular structures efficiently.

The compound’s key properties include its ability to form specific bonds through click chemistry mechanisms, ensuring high efficiency and stability in chemical reactions. The presence of aminooxy groups allows for reliable and reproducible conjugation processes, which are vital in the synthesis of bioconjugates and molecular probes. Additionally, its chemical stability under controlled conditions ensures that it remains effective for extended periods, making it a preferred choice for laboratories requiring consistent results.

In Indonesian laboratories, this compound is commonly used in research related to biochemistry, pharmaceutical development, and biotechnology. It is particularly favored for its role in creating molecular frameworks for drug development and diagnostic applications. Its versatility and reliability make it a staple in academic and industrial research settings across Indonesia.

Advantages (TCI brochure)

Formation of cross-linked duplex by selective reaction towards abasic site of DNA duplex
Rigid, thermo- and enzyme stable cross-linked DNA
General usage as a diamine cross-linker

TCI brochures (PDF)

Cross-linker to Stabilize DNA Duplexes 2022-10-18 · p. 1

Related TCI products

Bioconjugate synthesis: This compound is ideal for creating stable molecular linkages in bioconjugate applications due to its click chemistry properties.
Drug development: Its ability to form specific molecular bonds supports the synthesis of complex drug molecules in pharmaceutical research.
Diagnostic reagent formulation: The compound’s stable and efficient conjugation properties make it suitable for use in diagnostic reagents and molecular probes.
Molecular imaging studies: Its structural versatility enables its use in the development of imaging agents for biological and medical research.
Biotransformation studies: The compound’s chemical stability and reactivity make it a useful tool in studying molecular transformations and interactions.

From the TCI brochure

Cross-linking of DNA duplexes at abasic sites
General use as a diamine cross-linker
Extra stable double strands with nuclease resistance (as shown in the application scheme)

Brand	TCI
CAS number	1166232-68-3
Molecular formula	—
Purity	—
Category	Chemistry > Chemical Biology > Conjugation Chemistry/Click Chemistry
Pack sizes	Available in standard laboratory quantities as per supplier specifications
Physical form	Solid powder
Storage	Store in a cool, dry place away from light and moisture

Data from the TCI brochure

Kemasan	100mg

Source: TCI brochure RR153 (2022-10-18)

This compound should be stored in a cool, dry environment, away from direct light and moisture to maintain its chemical stability. It is recommended to use airtight containers to prevent exposure to air and humidity, which could affect its performance. Proper labeling of storage containers is essential for safe handling and to avoid cross-contamination. In laboratory settings, it is important to handle the compound with appropriate personal protective equipment, such as gloves and safety goggles, to ensure safety. Regular inspection of storage conditions is advised to ensure the compound remains in optimal condition for research applications.

References cited in the TCI brochure

Kohei Ichikawa. Interstrand cross-link of DNA by covalently linking a pair of abasic sites Chemical Communications, 2012. doi:10.1039/c2cc16785a
Yasuhiro Mie. Electrochemical Properties of Interstrand Cross-Linked DNA Duplexes Labeled with Nile Blue Langmuir, 2012. doi:10.1021/la3036538
Yasuhiro Mie. Function Control of Anti-microRNA Oligonucleotides Using Interstrand Cross-Linked Duplexes Molecular Therapy Nucleic Acids, 2018. doi:10.1016/j.omtn.2017.11.003
Sho Okumura. Inhibition of breast cancer cell proliferation with anti-microRNA oligonucleotides flanked by interstrand cross-linked duplexes Nucleosides, Nucleotides & Nucleic Acids, 2019. doi:10.1080/15257770.2019.1671595