TCI P2359 Pamabrom is an equimolar salt mixture of 8-bromotheophylline and 2-amino-2-methyl-1-propanol. Its active component, 8-bromotheophylline, is a xanthine derivative that is structurally related to theophylline and caffeine, which is why TCI lists it among its alkaloid biochemicals. Pamabrom is known as a mild diuretic and is often found in over-the-counter preparations for relieving premenstrual symptoms. In the laboratory, it serves as a standard or research material for analytical work and experimental pharmacology.
Laboratories choose pamabrom for its specific role as the diuretic active ingredient in combination formulations, where it is often paired with analgesics such as paracetamol. This role makes it an important reference material when developing and validating multicomponent analytical methods. Its brominated xanthine structure gives it a distinctive chromatographic profile and UV spectroscopic character, so analysts can readily tell it apart from other formulation components. As a quality research material from TCI, pamabrom gives a consistent reference point for identity, assay, and stability testing across repeated analytical runs.
In Indonesia, pamabrom is relevant to pharmaceutical analysis laboratories at universities, to pharmaceutical product development laboratories, and to quality control units that test combination formulations. Researchers working on multicomponent dosage forms can use it to build and verify HPLC or UV-based methods, while pharmacology groups can use it in experimental studies of xanthine-type diuretics. It also supports teaching laboratories that introduce students to method validation for combination pharmaceutical products.
TCI brochures (PDF)
- Alkaloids 2025-10-10 · p. 7
- Pharmaceutical Ingredients for Research and Experimental Use 2026-03-09 · p. 47
- Reference standard for HPLC method development: its distinctive chromatographic behavior lets analysts confirm separation of pamabrom from paracetamol and other active ingredients in combination formulations.
- Validation of multicomponent analytical methods: a consistent research-grade material supports evaluation of specificity, linearity, accuracy, and precision when several actives must be measured together.
- Identity and assay testing in quality control: the material provides a dependable comparison point for confirming the presence and content of pamabrom in finished pharmaceutical preparations.
- Stability studies of combination formulations: analysts can use pamabrom as a reference to track changes in the diuretic component over time under different storage conditions.
- Experimental pharmacology of xanthine derivatives: its structural relationship to theophylline and caffeine makes it a useful research compound for studying mild diuretic activity in controlled experiments.
| Brand | TCI (product code P2359) |
|---|---|
| CAS number | 606-04-2 |
| Molecular formula | — |
| Purity | — |
| Category | Life Science > Biochemicals and Reagents > Alkaloids |
| Pack sizes | see the product listing for available pack sizes |
| Physical form | — |
| Storage | follow the storage conditions on the TCI label and Safety Data Sheet |
- Composition: equimolar salt mixture of 8-bromotheophylline and 2-amino-2-methyl-1-propanol
Store pamabrom in its original, tightly closed manufacturer's container, in a cool, dry, well-ventilated place away from direct sunlight, moisture, and incompatible substances. Follow any specific storage temperature on the TCI label or Safety Data Sheet. Once opened, reseal the container promptly to keep out humidity and contamination. Wear standard laboratory personal protective equipment when handling the material, including gloves, safety glasses, and a lab coat. Avoid creating or breathing in dust, and weigh the material in a ventilated area or fume hood. Label working solutions clearly, record preparation dates, and dispose of waste according to institutional and local chemical waste regulations. Read the Safety Data Sheet before first use.
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Product Categories
- Biochemicals and ReagentsAlkaloidsPurine Alkaloids
- Biochemicals and ReagentsPharmaceutical Research Reagents (for Experimental Use)Pharmaceutical Research Reagents (Others)
- Pharmaceutical Development and Drug Discovery ResearchPharmaceutical Research Reagents (for Experimental Use)Pharmaceutical Research Reagents (Others)
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