PEG Dithiol 8000 TCI P2861

Chemical Identity

CAS No.: 68865-60-1

Rp 4.347.000,00

~~Rp 3.039.750,00~~ Rp 4.347.000,00

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TCI P2861 PEG Dithiol 8000 is a polyethylene glycol with a thiol group at each end and an average molecular weight of about 8000. It has the longest chain of the PEG dithiol variants in this series. Like the shorter variants, its two terminal thiol groups react with maleimides, acrylates, vinyl sulfones and norbornenes, form disulfide bonds, and anchor to gold surfaces. In the laboratory it is mainly used as a long, flexible crosslinker for building soft hydrogels and thick surface coatings.

The chain length of about 8000 puts the crosslink points far apart. Hydrogels made with this crosslinker tend to be softer and more elastic, absorb more water, and have a wider mesh size. This helps when researchers want to mimic the softness of the body's soft tissues, or when large molecules need to diffuse freely through the network. The long chain also reaches further when bridging two surfaces or particles. On a surface, it forms a thicker PEG layer, which helps suppress non-specific interactions. Because it reacts with several thiol-reactive groups, researchers can choose the crosslinking chemistry that best suits their system.

In Indonesia, this material supports cell culture research, biomaterials work and tissue engineering studies at universities, research institutes and biotechnology laboratories. Groups developing soft hydrogel scaffolds, three-dimensional cell culture matrices or controlled-release systems can use it to make networks that are more compliant and more permeable than those made with shorter PEG dithiols. Laboratories working with gold nanoparticles, sensor chips or modified surfaces can also use it to build thicker PEG layers that resist fouling.

TCI brochures (PDF)

Biomaterials Research Reagents 2025-02-19 · p. 6
Monomers 2025-05-28 · p. 27

Related TCI products

Soft hydrogel fabrication: the long PEG chain of about 8000 spaces the crosslinks widely, producing soft, elastic, highly swollen gels with a wide mesh size.
Three-dimensional cell culture matrices: the soft networks can mimic the compliance of soft body tissues and let nutrients and large molecules diffuse freely to the cells.
Thiol-Michael and thiol-ene crosslinking: both thiol ends react with maleimide, acrylate, vinyl sulfone or norbornene groups, so researchers can choose the network chemistry they need.
Gold surface and nanoparticle modification: the terminal thiols anchor to gold, and the long chain forms a thick PEG layer that helps suppress non-specific interactions.
Bridging particles or surfaces: the long, flexible chain reaches further than shorter PEG dithiols, so it can link two surfaces, particles or functional components spaced further apart.

Brand	TCI (product code P2861)
CAS number	68865-60-1
Molecular formula	approximately 8000
Purity	—
Category	Chemistry > Chemical Biology > PEGylation
Pack sizes	please contact AMI Scientific for the pack sizes currently available
Physical form	—
Storage	keep tightly closed and follow the storage conditions on the TCI label and Safety Data Sheet

Store PEG Dithiol 8000 in its original, tightly sealed container, away from moisture, heat and direct light, under the conditions shown on the TCI label and Safety Data Sheet. Thiol groups can slowly oxidize to disulfides when exposed to air. Keep exposure to air short, reseal the container promptly after use, and consider blanketing it with an inert gas such as nitrogen or argon. Keep it away from oxidizing agents. Wear gloves, safety glasses and a lab coat, avoid generating dust or contacting skin and eyes, and handle it in a well-ventilated area. Prepare reactive solutions fresh where possible, and dispose of waste according to institutional and local regulations.

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