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Description
Quinoline N-Oxide Hydrate from TCI, with CAS number 198878-42-1, is a nitrogen-containing heterocyclic compound that plays an important role as a building block in organic synthesis within the chemistry laboratory. The compound is a quinoline derivative that has undergone oxidation at the nitrogen atom, resulting in the formation of a reactive and versatile N-oxide group. In laboratory practice, this material is commonly used to build substituted quinoline frameworks, which are frequently encountered in pharmaceutical compounds, agrochemicals, and functional materials.
The key advantage of Quinoline N-Oxide Hydrate lies in the reactivity of its N-oxide group, which allows the compound to participate in a wide range of reactions, including C-H activation, oxidation reactions, and the formation of carbon-heteroatom bonds. This versatility makes it a preferred choice for chemists seeking a dependable reagent for constructing nitrogen-containing heterocyclic scaffolds. In addition, its hydrate form provides stability and ease of handling during storage and weighing, which is highly valued in routine laboratory workflows.
In Indonesian laboratories, this material strongly supports research in organic chemistry, medicinal chemistry, and the development of synthetic methodologies that require nitrogen-containing heterocyclic frameworks. Academic institutions and research facilities commonly employ it as a starting material for preparing quinoline-based intermediates used in drug discovery programs and in the synthesis of functional compounds. As part of the TCI range supplied to the Indonesian market, it provides local researchers with a reliable, high-quality building block for advancing experimental work in heterocyclic chemistry.
Laboratory Applications
- Precursor in cross-coupling reactions: The N-oxide functionality enables this compound to serve as a precursor in cross-coupling reactions, allowing the construction of substituted quinoline derivatives with defined connectivity.
- Substrate in transition-metal-catalyzed reactions: It acts as a substrate in transition-metal-catalyzed reactions, where the reactive N-oxide group participates in catalytic cycles that functionalize the heterocyclic ring under mild conditions.
- Oxygen atom source in oxidative transformations: The compound serves as a source of oxygen atoms in various oxidative transformations, making it a practical oxidant or oxygen-transfer reagent for laboratory-scale synthesis.
- C-H activation studies: Its reactive N-oxide group makes it a useful substrate for C-H activation studies, in which researchers investigate selective functionalization of the quinoline core to generate valuable new derivatives.
- Scaffold for medicinal chemistry programs: As a nitrogen-containing heterocyclic building block, it is used to assemble quinoline scaffolds for medicinal chemistry programs, supporting the preparation of pharmaceutically relevant intermediates and candidates.
Specifications
- Brand: TCI
- Product code: Q0072
- CAS number: 198878-42-1
- Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
- Physical form: supplied as a hydrate, per the product name
- Storage note: store in a cool, dry place, protected from moisture
Handling and Storage
Store Quinoline N-Oxide Hydrate in a cool, dry, and well-ventilated area, protected from direct sunlight and excessive moisture. Keep the container tightly closed when not in use to preserve the integrity of the hydrate form. Use the original container or a compatible chemical-resistant laboratory bottle for storage, and label it clearly with the product name and CAS number. Wear appropriate personal protective equipment, such as laboratory gloves, safety goggles, and a laboratory coat, when handling the material. Avoid inhalation of dust and contact with skin or eyes, and work in a fume hood whenever possible. Keep the material away from incompatible substances and open flames, and follow standard laboratory waste disposal procedures for chemical reagents.
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