Side Chain Protected Amino Acids (N,C-termini Free) — covers amino acids with protecting groups on the side chain while the terminal amine and carboxylic acid groups remain free, such as O-tert-Butyl-L-serine and S-Trityl-L-cysteine. The tert-butyl, trifluoroacetyl, or trityl protecting groups in this group keep side-chain reactivity under control throughout peptide synthesis steps.
Side Chain Protected Amino Acids are used by peptide chemistry researchers as building blocks in solid-phase and solution-phase peptide synthesis, especially when side-chain functional groups such as hydroxyl, carboxylic acid, or thiol need temporary protection while the N and C-terminus remain available for coupling reactions. Compounds such as 5-tert-Butyl L-Glutamate and 4-tert-Butyl L-Aspartate help prevent side reactions on acid chains, while Nepsilon-Trifluoroacetyl-L-lysine protects the side-chain amine group of lysine.
Examples of products in this collection: TCI T2815 10009-20-8 Nepsilon-Trifluoroacetyl-L-lysine, TCI C0034 1155-64-2 Nepsilon-Carbobenzoxy-L-lysine, TCI T2522 2799-07-7 S-Trityl-L-cysteine, TCI C0863 638-23-3 S-(Carboxymethyl)-L-cysteine, TCI B4045 2419-56-9 5-tert-Butyl L-Glutamate, TCI D1023 14401-10-6 Nepsilon-(2,4-Dinitrophenyl)-L-lysine Hydrochloride, TCI B3919 3057-74-7 4-tert-Butyl L-Aspartate, TCI E1155 1119-33-1 5-Ethyl L-Glutamate.
Selection should consider the type of protecting group used, its compatibility with the planned deprotection strategy, and the L stereochemistry of the chosen amino acid. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.
Other sibling categories under Amino Acid Derivatives [Peptide Chemistry], often used together in one laboratory workflow:
Back to Amino Acid Derivatives [Peptide Chemistry]. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.
