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TCI

CAS 91421-43-1

9-Aminocamptothecin TCI A2063

9-Aminocamptothecin TCI A2063

Chemical Identity

CAS No.
91421-43-1
PubChem
CID 72402·SID 87560557
Formula
C20H17N3O4
Molecular weight
363.4 g/mol
Purity
>95.0%(HPLC)
Reference databases
ChEBI·ChemSpider
Full identifiers (IUPAC, SMILES, InChIKey)
IUPAC
(19S)-8-amino-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
SMILES
CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=C(C=CC=C5N=C4C3=C2)N)O
InChIKey
FUXVKZWTXQUGMW-FQEVSTJZSA-N
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9-Aminocamptothecin is a chemical compound belonging to the alkaloid category, widely used in biochemical and pharmacological research. It plays a crucial role in laboratories by serving as a reagent for studying the mechanisms of cancer drugs and the development of new anti-cancer therapies. This compound is particularly valuable for its ability to inhibit the growth of rapidly dividing cancer cells, making it a key tool in cancer research. Its unique chemical structure and biological activity contribute to its significance in scientific investigations aimed at understanding and combating cancer.

The compound's specificity toward the enzyme topoisomerase I makes it a preferred choice in research focused on DNA replication and cell division. Its chemical and physical properties, including stability under certain conditions and good solubility in organic solvents, further enhance its utility in laboratory settings. These characteristics ensure reliable and reproducible results, making it a trusted material for high-precision experiments. Additionally, its solid form facilitates accurate weighing and handling in various research scales.

In Indonesian laboratories, 9-Aminocamptothecin is commonly used in cancer and pharmacology research. It is highly relevant for studies aimed at developing targeted therapies and understanding the molecular mechanisms of cancer progression. Its availability and consistent performance make it an essential component in the research toolkit of Indonesian scientists working in life sciences and medicinal chemistry.

  • Cancer Research: 9-Aminocamptothecin is used to study the mechanisms of DNA damage and cell death in cancer cells, aiding in the development of targeted therapies.
  • Pharmacological Studies: It serves as a model compound for investigating the pharmacodynamics and pharmacokinetics of anti-cancer agents.
  • Enzyme Inhibition Studies: Its specificity toward topoisomerase I makes it ideal for research on enzyme inhibition and DNA repair processes.
  • Drug Development: It is utilized in the screening of potential anti-cancer compounds and the evaluation of their efficacy.
  • Biochemical Analysis: Its chemical stability and solubility make it suitable for use in biochemical assays and molecular biology experiments.

Brand TCI
CAS number 91421-43-1
Molecular formula —
Purity —
Category Life Science > Biochemicals and Reagents > Alkaloids
Pack sizes Available in various quantities as per supplier specifications
Physical form Solid
Storage Store in a cool, dry place away from light

9-Aminocamptothecin should be stored in a cool, dry environment, away from direct light to maintain its chemical stability. It is recommended to use airtight containers to prevent moisture absorption and contamination. Due to its potential reactivity, it should be handled with appropriate personal protective equipment, such as gloves and safety goggles, to ensure laboratory safety. The compound should be kept in a well-ventilated area to minimize exposure. Proper labeling of storage containers is essential for safe handling and easy identification. Regular monitoring of storage conditions is advised to ensure the compound remains in optimal condition for research use.

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