TCI
2,2,2-Trichloroethyl Chloroformate TCI C0795
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Description
TCI C0795 2,2,2-Trichloroethyl Chloroformate (CAS 17341-93-4) is the standard reagent for introducing the Troc protecting group onto amines and alcohols. Troc protection is valued for its orthogonality, since it can be removed reductively — typically with zinc — without disturbing acid- or base-labile protecting groups. The reagent is also used to prepare carbamates and carbonates in carbohydrate, peptide, and natural product synthesis. Supplied by TCI in 25 g and 250 g packs, it is moisture-sensitive and corrosive, and must be handled dry in a fume hood.
Scientific References
- HE et al. (1991). ChemInform Abstract: Di‐(2,2,2‐Trichloroethyl) Carbonate: By‐Product in Reactions with 2,2, 2‐Trichloroethyl Chloroformate.. ChemInform doi:10.1002/chin.199110106
- He et al. (1990). DI-(2,2,2-Trichloroethyl)-Carbonate: Byproduct in Reactions with 2,2,2-Trichloroethyl Chloroformate. Synthetic Communications doi:10.1080/00397919008053155
- Oliveira dos Reis (2007). 2,2,2-Trichloroethyl Chloroformate (TrocCl). Synlett doi:10.1055/s-2007-980374
References were compiled automatically from Crossref and every DOI was verified to exist. AMI Scientific is not affiliated with the authors or the publishers.
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