TCI C1292 1,4-Cyclohexanedione Monoethyleneketal is a mono-protected building block in which one carbonyl of 1,4-cyclohexanedione is masked as an ethylene ketal. This selective protection lets chemists functionalise a single ketone site while the second remains safely blocked until acidic aqueous deprotection. It is widely applied in the construction of 4-substituted cyclohexanones, spirocyclic frameworks, and medicinal chemistry scaffolds. AMI Scientific supplies this TCI reagent in several pack sizes to match both exploratory and preparative laboratory work.
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- Starostin et al. (1993). Synthesis of derivatives of ketocarboxylic acids by the decomposition of 1,4-cyclohexanedione monoethyleneketal hydroperoxide. Russian Chemical Bulletin doi:10.1007/bf00702000
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