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Description
Trisodium Glycyrrhizinate is the trisodium salt of glycyrrhizic acid, a triterpenoid saponin that serves as the principal active constituent of licorice root. In this sodium salt form, a compound that is otherwise poorly soluble becomes far more readily soluble in water, making it practical for solution-based experimental work. Its molecular structure consists of a triterpenoid aglycone core linked to two glucuronic acid units, which makes the compound an instructive example within glycoscience studies and a useful reference material in the laboratory.
The properties that make this compound a preferred choice begin with its good solubility in water as a trisodium salt, which simplifies preparation of aqueous working solutions. Like saponins in general, it lowers surface tension, a behaviour that is relevant in a range of experimental settings. It also carries an intensely sweet taste that far exceeds that of sucrose, which has made it an object of research into natural sweeteners. Biologically, glycyrrhizic acid and its derivatives have been widely studied for anti-inflammatory, antiviral, and hepatoprotective activity.
In Indonesian laboratories this material is used as an analytical standard, as a test compound in pharmacological and anti-inflammatory research, and as a comparison substance in quality testing of medicinal plant extracts. The glucuronic acid portion of the structure makes it a good model for studying glycoside-related chemistry, so it appears in academic research groups, natural product laboratories, and quality control settings that examine herbal and phytopharmaceutical materials.
Laboratory Applications
Analytical standard preparation: the compound serves as a reference substance for identification and comparison work, with its salt form giving reliable dissolution in aqueous systems used for routine analysis.
Pharmacological research: used as a test compound in studies of anti-inflammatory activity, where glycyrrhizic acid and its derivatives have an established record as subjects of biological investigation.
Medicinal plant extract quality testing: acts as a comparison material when assessing licorice-containing or herbal extracts, since it represents the principal active constituent of licorice root.
Glycoscience and glycoside model studies: the two glucuronic acid units attached to the triterpenoid aglycone make it a practical model compound for teaching and studying glycoside chemistry.
Natural sweetener research: its intense sweetness far beyond that of sucrose makes it a subject compound in investigations of naturally derived sweetening agents and their properties.
Specifications
Brand: TCI
Product code: G0217
CAS number: 71277-78-6
Category: Chemistry > Chemical Biology > Glycoscience
Chemical class: trisodium salt of glycyrrhizic acid, a triterpenoid saponin
Pack sizes: available in standard laboratory catalogue pack sizes; please confirm the size required when ordering
Storage: store according to the manufacturer's label instructions
Handling and Storage
Store the container tightly closed in a cool, dry place away from direct sunlight and sources of heat, following the storage conditions stated on the manufacturer's label. Keep the material in its original container or in a well-sealed glass or chemically compatible plastic vessel, clearly labelled with the substance name and CAS number. Because the compound is readily soluble in water, protect it from moisture to avoid caking and to maintain accurate weighing. Handle the powder in a well-ventilated area or fume hood to limit dust generation, and wear a laboratory coat, gloves, and eye protection during weighing and solution preparation. Use clean, dry spatulas to prevent cross-contamination of the stock, and prepare aqueous solutions fresh where analytical accuracy is important. Dispose of residues and used solutions in accordance with the laboratory's chemical waste procedures.
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