Proteolysis Targeting Chimera Research Reagents — includes chemical building blocks such as PEG linkers, TCO-PEG-DBCO compounds, and Boc-amino-PEG-acid derivatives, which serve as linker components in the assembly of PROTAC molecules and other bifunctional conjugates.
These reagents are used in the synthesis of PROTAC-based protein degrader molecules, bioorthogonal click conjugation, and the preparation of labeled probes for chemical biology research. Medicinal chemistry and chemical biology researchers use variations in PEG linker length and terminal reactive groups to optimize the distance and orientation between fragments of the target molecule.
Examples of products in this collection: TCI T4239 TCO-PEG3-DBCO equatorial isomer, TCI B5586 252881-74-6 Amino-PEG3-acid tert-Butyl Ester, TCI T4238 TCO-PEG3-DBCO axial isomer, TCI B5665 756525-91-4 (Boc-amino)-PEG4-carboxylic Acid, TCI T4237 TCO-PEG3-Biotin equatorial isomer, TCI B5683 127828-22-2 N-(tert-Butoxycarbonyl)-2-(2-aminoethoxy)ethylamine, TCI T4236 TCO-PEG3-Biotin axial isomer, TCI B5900 581065-95-4 tert-Butyl 1-Amino-3,6,9,12-tetraoxapentadecan-15-oate.
Note the length of the PEG chain, the type of terminal reactive group (amine, acid, DBCO, or TCO), and the geometric isomers (axial/equatorial) of certain TCO compounds. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on the page of each item.
Other categories at the same level under Pharmaceutical Development and Drug Discovery Research Reagents, often used together in a single laboratory workflow:
Back to Pharmaceutical Development and Drug Discovery Research Reagents. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — official TCI Japan distributor in Indonesia — for availability checks and lead times directly from Japan.
