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TCI

CAS 634-35-5

Quinoline Ethiodide TCI E0173

Quinoline Ethiodide TCI E0173
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Description

TCI E0173 Quinoline Ethiodide is a quaternary salt of quinoline in which the ring nitrogen atom has been ethylated, with an iodide ion serving as the accompanying anion. The compound is classified as a heterocyclic building block because the quinoline framework carries a nitrogen atom within its fused aromatic ring system. In the laboratory, N-ethylquinolinium salts of this type are used as starting materials for the synthesis of charged heterocyclic compounds, as substrates in studies of reduction and hydride transfer reactions, and as components in the preparation of quinoline-based dyes and functional materials.

The property that makes this compound a preferred choice is the electron-deficient character that arises from the positive charge residing on the nitrogen atom. The quinolinium ring becomes far more readily attacked by nucleophiles and hydride donors than neutral quinoline, which makes the compound a clean substrate for studying addition reactions on heteroaromatic rings and the formation of dihydroquinoline derivatives. Unlike quinaldine derivatives, this compound has no activated methyl group at the 2-position, so reactivity is directed at the ring itself rather than at a side chain.

As an ionic salt supplied in solid form, the compound dissolves well in polar solvents and is straightforward to weigh out. This combination suits the working conditions of Indonesian laboratories, where synthetic chemistry groups in universities and research institutes prepare heterocyclic intermediates on a small scale, and where a solid that can be measured accurately on an analytical balance and dissolved directly in a polar medium simplifies reaction setup without requiring specialised transfer equipment.

Laboratory Applications

  • Synthesis of charged heterocyclic compounds — the pre-formed N-ethylquinolinium cation supplies the quaternised nitrogen centre directly, removing the need for a separate alkylation step in the reaction sequence.
  • Hydride transfer studies — the electron-deficient quinolinium ring accepts hydride readily, making the compound a reliable substrate for tracking hydride delivery to a heteroaromatic system.
  • Reduction reaction investigations — the positive charge on nitrogen lowers the barrier to reduction relative to neutral quinoline, giving a clean and predictable substrate for comparative reduction work.
  • Preparation of dihydroquinoline derivatives — nucleophilic and hydride addition across the activated ring provides a direct route to dihydroquinoline products from a single solid starting material.
  • Quinoline-based dye and functional material preparation — the quinolinium framework serves as a component in building dyes and functional materials that rely on a charged quinoline core.

Specifications

  • Brand: TCI
  • CAS number: 634-35-5
  • Category: Chemistry > Building Blocks > Heterocyclic Building Blocks
  • Pack sizes: available in the standard TCI catalogue pack sizes; please confirm the required size when ordering
  • Physical form: solid ionic salt
  • Storage: keep in the closed original container under the conditions stated on the manufacturer's label and safety data sheet

Handling and Storage

Store the material in its original tightly closed container, kept in a cool, dry and well-ventilated area away from moisture, since ionic salts of this type can pick up water from humid air. Glass or other chemically compatible containers with secure closures are suitable for storage and for any subdivided portions. Handle the solid in a fume hood or well-ventilated workspace, wearing safety glasses, gloves and a laboratory coat, and avoid generating or inhaling dust during weighing and transfer. Keep the container closed when not in use, label all subdivided material clearly, and consult the manufacturer's safety data sheet before handling for the full set of hazard and first-aid information.

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