Hexaethylene Glycol TCI H1432

Hexaethylene Glycol is a defined-length oligomer of ethylene glycol built from six consecutive ethylene oxide units, with a free hydroxyl group at each end of the chain. Unlike commercial polyethylene glycol, which is a mixture of chains of varying lengths, this compound is monodisperse: the chain length is uniform and the number of repeating units is known exactly. In the laboratory, this property is what makes it a material of choice for constructing PEG linkers in bioconjugation research, chemical biology, and the design of targeted molecules.

The characteristics that drive its selection include excellent solubility in both water and many polar organic solvents, high chain flexibility, and the biocompatible, low-immunogenicity behaviour long recognised in polyethylene glycol chains. Its two terminal hydroxyl groups are symmetrical and readily activated to tosylates, mesylates, azides, amines, or carboxylic acids, so the chain can be joined to two different molecules. The uniformity of the chain length also matters for characterisation, because the compound has a single molecular mass and mass spectrometry data are therefore straightforward to interpret.

In Indonesian laboratories, this material is typically held by research groups and institutional facilities working on bioconjugation, chemical biology, and targeted molecular design, where a linker of exactly known length is required rather than a polydisperse mixture. It is handled as a synthetic building block on the bench: activated at one or both termini, then coupled into a larger construct. Its clean analytical profile suits groups that must confirm the identity of each intermediate by mass spectrometry before proceeding.

• Bioconjugation linker synthesis: the two symmetrical terminal hydroxyl groups can be activated separately, letting researchers bridge two different molecules through a spacer of exactly known length.
• PEGylation chemistry: the monodisperse six-unit chain confers the solubility, flexibility, and low immunogenicity associated with polyethylene glycol without the length heterogeneity of commercial PEG mixtures.
• Targeted molecule design: a defined chain length gives reproducible spacing between a targeting element and its payload, which matters when geometry influences binding behaviour.
• Terminal group derivatisation: the hydroxyl ends are readily converted to tosylate, mesylate, azide, amine, or carboxylic acid functionalities for onward coupling chemistry.
• Analytical characterisation work: because the material has a single molecular mass rather than a distribution, mass spectrometry data on intermediates and conjugates are easy to interpret.

• Catalogue number: H1432

Store the container tightly closed in a cool, dry, well-ventilated area, away from heat sources and direct sunlight, and follow the storage conditions given on the manufacturer's label and safety data sheet. Keep the material in its original container or in a compatible, clearly labelled chemically resistant vessel; because polyethylene glycol chains are hygroscopic, minimise exposure to open air when the reagent is intended for moisture-sensitive derivatisation. Handle in a fume hood using safety goggles, gloves, and a laboratory coat, avoid contact with skin and eyes, and consult the safety data sheet before first use. Dispose of residues and contaminated materials in accordance with applicable institutional and local chemical waste regulations.

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