Collection: Coupling [Synthetic Reagents]

Coupling [Synthetic Reagents] — covers reagents that form amide, ester, and other derivative bonds in organic synthesis, including carbodiimides, phosphonium/uronium/formamidinium salts, phosgene derivatives, active esters and additives, and triflate-forming reagents. This group activates carboxylic acid or alcohol groups so that they react efficiently with their paired nucleophiles.

Coupling reagents are widely used in solid-phase and solution-phase peptide synthesis, in forming amide bonds in candidate molecules for research, and in converting alcohols or phenols into triflates for transition-metal coupling reactions such as Suzuki and Negishi. Synthetic chemists in academic laboratories and pharmaceutical research use them to accelerate bond formation with minimal racemization or side effects.

Example products in this collection: TCI T3592 15458-53-4 Trifluoromethanesulfonyl Bromide, TCI C0119 530-62-1 1,1'-Carbonyldiimidazole [Coupling Agent for Peptides Synthesis], TCI T3569 255825-38-8 N,N,N',N'-Tetramethyl-S-(1-oxido-2-pyridyl)thiouronium Tetrafluoroborate, TCI C0178 543-27-1 Isobutyl Chloroformate, TCI T3177 29540-81-6 1-(Trifluoromethanesulfonyl)imidazole, TCI C0597 1079-66-9 Chlorodiphenylphosphine, TCI T3167 117632-84-5 1-(Trifluoromethanesulfonyl)-1H-benzotriazole, TCI C0793 2491-17-0 1-Cyclohexyl-3-(2-morpholinoethyl)carbodiimide Metho-p-toluenesulfonate [for Peptide Synthesis].

Choose the reagent type according to the functional group being activated (carboxylic acid, alcohol, or amine), and consider reaction efficiency, ease of separating by-products, and storage stability of the reagent, which is generally sensitive to moisture. All products are genuine Tokyo Chemical Industry (TCI) Japan products, with purity, packaging, and storage conditions listed on each item's page.

Other categories at the same level under Organic Synthesis Reagents, often used together in a single laboratory workflow:

• C-C Bond Formation [Synthetic Reagents]
• C-X(Non-Halogen) Bond Formation [Synthetic Reagents]
• Protection, Deprotection, Derivatization
• Acids, Bases [Synthetic Reagents]
• Chelation/Complexation Compounds
• Phase Transfer Catalysts

This collection is further divided into 7 more specific groups:

• Peptide Coupling Agents
• Active Esters, Additives [Coupling Reagents]
• Phosphonium Salts, Uronium Salts, Formamidinium Salts [Coupling Reagents]
• Coupling Reagents (Other)
• Triflate Formation [Coupling Reagents]
• Carbodiimides [Coupling Reagents]
• Phosgene Derivatives [Coupling Reagents]

Back to Organic Synthesis Reagents. For large-volume procurement, special packaging, or specific grades, contact the AMI Scientific team — the official TCI Japan distributor in Indonesia — to check availability and lead time directly from Japan.